DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3918:3922

E3 ligase: SPOP

DEGRON score: 0.835

ASA_SCORE: 98.2

COIL: 0.8676

CONS_SCORE: 0.2917

DSS_SCORE: 0.586

HELIX: 0.0206

FCONS_SCORE: 1.0642

RIG_SCORE: 0.7901

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3910S	TCGA-18-3409	LUSC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111
p.T3923S	TCGA-34-5929	LUSC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.3056
p.S3908F	TCGA-EE-A29D	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	0.0556
p.G3911E	TCGA-T3-A92M	HNSC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1389
p.G3911R	TCGA-W3-A824	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1389
p.S3930F	TCGA-ZF-AA4X	BLCA	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111
p.V3912I	DO229010	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.V3912I	DO229013	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.V3912I	DO229016	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.V3912I	DO229003	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.V3912I	DO229005	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.V3912I	DO229346	LAML	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.V3912I	DO218878	SKCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.V3912I	DO229221	THCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.G3914E	DO223269	HNSC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.P3913S	DO26444	LUSC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1944
p.T3926S	DO26659	LUSC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.T3918P	DO229453	SKCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7031
p.G3914R	DO51271	SKCM	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.S3911F	DO38123	SKCM	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1389
p.A3930S	DO229245	THCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1111
p.S3908T	SIDM00643	Non-Cancerous	GDSC	VLTTT	DEG_SPOP_SBC_1	0.0556
p.S3908T	ACH-000327	Lung Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.0556
p.S3908T	ACH-002363	Non-Cancerous	CCLE	VLTTT	DEG_SPOP_SBC_1	0.0556
p.V3926E	SIDM00954	Breast Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.V3926E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons