DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3279:3283

E3 ligase: SPOP

DEGRON score: 0.9759

ASA_SCORE: 100.54

COIL: 0.9084

CONS_SCORE: 0.3375

DSS_SCORE: 0.6181

HELIX: 0.0222

FCONS_SCORE: 0.983

RIG_SCORE: 0.7703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3270S	TCGA-66-2763	LUSC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.0833
p.T3283M	TCGA-EY-A549	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.7423
p.G3291S	TCGA-UD-AAC1	MESO	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111
p.T3287A	DO222809	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.T3287A	DO229016	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.T3287A	DO229003	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.T3287A	DO229005	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.T3273S	DO27620	LUSC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.T3286M	DO48174	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.25
p.T3273I	SIDM00965	Small Cell Lung Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.T3273I	ACH-000800	Lung Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.1667
p.T3273I	NCI-H446	lung	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.R3288S	SIDM01442	Glioma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.1944
p.R3288G	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons