DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4651:4655

E3 ligase: SPOP

DEGRON score: 0.812

ASA_SCORE: 100.2

COIL: 0.8826

CONS_SCORE: 0.3545

DSS_SCORE: 0.586

HELIX: 0.0212

FCONS_SCORE: 1.1462

RIG_SCORE: 0.8011

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R4653T	DO229052	LICA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7876
p.A4652S	DO228952	LICA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7588
p.A4652T	DO218974	PAAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7139
p.T4654N	TCGA-97-7554	LUAD	TCGA	VLTTT	DEG_SPOP_SBC_1	0.7055
p.A4649T	TCGA-QR-A70G	PCPG	TCGA	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649T	TCGA-YH-A8SY	PAAD	TCGA	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649T	SIDM00683	Prostate Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649T	SIDM00783	Colorectal Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649T	ACH-000971	Colon/Colorectal Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.2778
p.T4657N	DO23592	LUAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.T4657A	DO229216	THCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649P	SIDM01093	Cervical Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649P	SIDM00534	Colorectal Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649P	ACH-000556	Cervical Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649P	ACH-000986	Colon/Colorectal Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.2778
p.A4649P	ACH-002847	Unknown	CCLE	VLTTT	DEG_SPOP_SBC_1	0.2778
p.T4648A	DO41020	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.25
p.G4647E	DO38159	SKCM	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.P4646L	DO26494	LUSC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1944
p.P4646Q	DO36299	PRAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1944
p.T4645A	TCGA-E6-A1LX	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1667
p.G4644E	TCGA-FW-A3TV	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1389
p.P4643L	TCGA-63-7023	LUSC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111
p.P4643Q	TCGA-G9-6342	PRAD	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111

Showing 1 to 24 of 24 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...

Showing 1 to 17 of 17 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons