DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3836:3840

E3 ligase: SPOP

DEGRON score: 0.5559

ASA_SCORE: 93.78

COIL: 0.7674

CONS_SCORE: 0.27

DSS_SCORE: 0.6354

HELIX: 0.029

FCONS_SCORE: 0.919

RIG_SCORE: 0.7674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3848S	TCGA-77-8128	LUSC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111
p.G3848S	TCGA-B5-A3FC	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111
p.G3848S	TCGA-D1-A17Q	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111
p.G3848S	SIDM00068	Colorectal Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.1111
p.G3848S	GEO	large_intestine	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.1111
p.A3841V	TCGA-D9-A6EC	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	0.3056
p.A3846V	TCGA-EE-A181	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1667
p.A3849V	DO37444	SKCM	ICGC	VLTTT	DEG_SPOP_SBC_1	0.5278
p.A3844V	DO50291	SKCM	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.A3841T	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.3056
p.A3846T	SIDM01045	Endometrial Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.A3846T	SIDM01449	Pancreatic Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.A3846T	ACH-000961	Endometrial/Uterine Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.1667
p.A3846T	ACH-000978	Endometrial/Uterine Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.1667
p.A3846T	EN	endometrium	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.1667
p.T3842I	SIDM00150	Colorectal Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.T3842I	ACH-000969	Colon/Colorectal Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.2778
p.T3842I	KM12	large_intestine	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons