DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 2661:2665

E3 ligase: SPOP

DEGRON score: 0.9314

ASA_SCORE: 100.56

COIL: 0.9248

CONS_SCORE: 0.22

DSS_SCORE: 0.5966

HELIX: 0.018

FCONS_SCORE: 1.0053

RIG_SCORE: 0.7877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2651C	TCGA-G2-AA3C	BLCA	TCGA	VLTTT	DEG_SPOP_SBC_1	0.0556
p.S2654C	DO51883	BLCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1389
p.P2652H	DO23580	LUAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.0833
p.S2651F	SIDM00007	Other Solid Cancers	GDSC	VLTTT	DEG_SPOP_SBC_1	0.0556
p.S2651F	ACH-001550	Skin Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.0556
p.S2651F	MCC13	skin	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.0556
p.P2653Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VLTTT	DEG_SPOP_SBC_1	0.1111
p.P2659A	CHSA0011	bone	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.P2659A	H290	pleura	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.I2652V	M14	skin	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.0833
p.I2652V	OV-17R	ovary	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.0833
p.I2652V	HPAC	pancreas	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.0833
p.H2657P	OV-17R	ovary	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons