DegronMD

Uniprot ID: O75122

Source protein: CLIP-associating protein 2

Source gene: CLASP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 1037:1043

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9893

ASA_SCORE: 88.4429

COIL: 0.5877

CONS_SCORE: 0.2406

DSS_SCORE: 0.4444

HELIX: 0.3787

FCONS_SCORE: 1.0788

RIG_SCORE: 0.7606

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1039C	TCGA-QQ-A8VF	SARC	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R1039C	ACH-000952	Prostate Cancer	CCLE	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R1040C	SIDM01664	Prostate Carcinoma	GDSC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.8301
p.S1039R	SCaBER	urinary_tract	COSMIC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.7427
p.D1040Y	DO37444	SKCM	ICGC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.7325
p.D1040Y	DO47672	SKCM	ICGC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.7325
p.N1034H	TCGA-QR-A70J	PCPG	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.6944
p.E1037D	TCGA-A5-A0G9	UCEC	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.6758
p.R1044L	TCGA-AP-A1E1	UCEC	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.H1045L	DO23740	LUAD	ICGC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1035N	DO38823	STAD	ICGC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1050Y	NCI-H1688	lung	COSMIC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D1030Y	NCI-H1688	lung	COSMIC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E1051Q	TCGA-IG-A4P3	ESCA	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1051Q	TCGA-QK-A6V9	HNSC	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S1028R	SCaBER	urinary_tract	COSMIC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	0.0833

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	LIG_APCC_ABBAyCdc20_2	1037:1043	KEAMFDD	APC,CDC20,FZR1	0.9893	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons