DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KEAMFDD
Uniprot ID:
O75122
Source protein:
CLIP-associating protein 2
Source gene:
CLASP2
Class:
LIG_APCC_ABBAyCdc20_2
Location:
1037:1043
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9893
ASA_SCORE:
88.4429
COIL:
0.5877
CONS_SCORE:
0.2406
DSS_SCORE:
0.4444
HELIX:
0.3787
FCONS_SCORE:
1.0788
RIG_SCORE:
0.7606
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E1037D
TCGA-A5-A0G9
UCEC
TCGA
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.6758
p.R1044L
TCGA-AP-A1E1
UCEC
TCGA
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.3056
p.E1051Q
TCGA-IG-A4P3
ESCA
TCGA
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.1111
p.E1051Q
TCGA-QK-A6V9
HNSC
TCGA
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.1111
p.R1039C
TCGA-QQ-A8VF
SARC
TCGA
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.8301
p.R1039C
ACH-000952
Prostate Cancer
CCLE
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.8301
p.N1034H
TCGA-QR-A70J
PCPG
TCGA
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.6944
p.H1045L
DO23740
LUAD
ICGC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.2778
p.D1040Y
DO37444
SKCM
ICGC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.7325
p.D1040Y
DO47672
SKCM
ICGC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.7325
p.D1035N
DO38823
STAD
ICGC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.2778
p.R1040C
SIDM01664
Prostate Carcinoma
GDSC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.8301
p.D1050Y
NCI-H1688
lung
COSMIC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.1389
p.D1030Y
NCI-H1688
lung
COSMIC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.1389
p.S1039R
SCaBER
urinary_tract
COSMIC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.7427
p.S1028R
SCaBER
urinary_tract
COSMIC
KEAMFDD
LIG_APCC_ABBAyCdc20_2
0.0833
Drug responses associated with CLASP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KEAMFDD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75122
CLIP-associating protein 2
LIG_APCC_ABBAyCdc20_2
1037:1043
KEAMFDD
APC,CDC20,FZR1
0.9893
More...