DegronMD

Uniprot ID: Q8WXI2

Source protein: Connector enhancer of kinase suppressor of ras 2

Source gene: CNKSR2

Class: DEG_SCF_FBW7_1

Location: 771:778

E3 ligase: FBXW7

DEGRON score: 0.8421

ASA_SCORE: 79.95

COIL: 0.7758

CONS_SCORE: 0.4266

DSS_SCORE: 0.3373

HELIX: 0.182

FCONS_SCORE: 1.0231

RIG_SCORE: 0.7764

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A762D	TCGA-17-Z033	LUAD	TCGA	LIETPLTS	DEG_SCF_FBW7_1	0.0833
p.Q769H	TCGA-37-4135	LUSC	TCGA	LIETPLTS	DEG_SCF_FBW7_1	0.2778
p.Q769H	TCGA-94-8035	LUSC	TCGA	LIETPLTS	DEG_SCF_FBW7_1	0.2778
p.Q769H	DO233865	GACA	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.2778
p.P775S	TCGA-78-8640	LUAD	TCGA	LIETPLTS	DEG_SCF_FBW7_1	0.6752
p.Q764R	TCGA-BR-8590	STAD	TCGA	LIETPLTS	DEG_SCF_FBW7_1	0.1389
p.P788S	TCGA-G4-6628	COAD	TCGA	LIETPLTS	DEG_SCF_FBW7_1	0.0556
p.P788S	SIDM00783	Colorectal Carcinoma	GDSC	LIETPLTS	DEG_SCF_FBW7_1	0.0556
p.P788S	ACH-000971	Colon/Colorectal Cancer	CCLE	LIETPLTS	DEG_SCF_FBW7_1	0.0556
p.P788S	HCT-116	large_intestine	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.0556
p.P774S	DO223732	CESC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.6752
p.P774S	DO222536	MELA	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.6752
p.P774S	DO42608	UCEC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.6752
p.R766H	DO222746	COCA	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.1944
p.R766H	SIDM00596	Endometrial Carcinoma	GDSC	LIETPLTS	DEG_SCF_FBW7_1	0.1944
p.R766H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LIETPLTS	DEG_SCF_FBW7_1	0.1944
p.R766H	ACH-000937	Leukemia	CCLE	LIETPLTS	DEG_SCF_FBW7_1	0.1944
p.R766H	ACH-001517	Endometrial/Uterine Cancer	CCLE	LIETPLTS	DEG_SCF_FBW7_1	0.1944
p.R766H	HEC-1	endometrium	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.1944
p.R766H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.1944
p.Q764H	DO14454	HNSC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.1389
p.H771D	DO23192	LINC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.7688
p.L786Q	DO26530	LUSC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.1111
p.R782K	DO222550	MELA	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.2222
p.P776T	DO47353	SKCM	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.7031
p.G788E	DO38111	SKCM	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.0556
p.C766Y	DO41235	UCEC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	0.1944
p.D770N	SIDM00007	Other Solid Cancers	GDSC	LIETPLTS	DEG_SCF_FBW7_1	0.3056
p.D770N	ACH-001550	Skin Cancer	CCLE	LIETPLTS	DEG_SCF_FBW7_1	0.3056
p.W768L	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	LIETPLTS	DEG_SCF_FBW7_1	0.25
p.W768L	ACH-000452	Esophageal Cancer	CCLE	LIETPLTS	DEG_SCF_FBW7_1	0.25
p.W768L	TE-8	oesophagus	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.25
p.A773V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.6936
p.I770V	NCI-H1915	lung	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.3056
p.I770V	CAL-39	vulva	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.3056
p.A768V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.25
p.P763S	HCT-116	large_intestine	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.1111
p.I775V	NCI-H1915	lung	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.7076
p.I775V	CAL-39	vulva	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.7076
p.Q785E	NCI-H2342	lung	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.1389
p.H774R	SK-MEL-24	skin	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LIETPLTS

Degron related mutations and impact score

Drug responses associated with CNKSR2 mutations

All proteins holding degron of LIETPLTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SCF_FBW7_1	771:778	LIETPLTS	FBXW7	0.8421	More...