DegronMD

Uniprot ID: Q9Y2H6

Source protein: Fibronectin type-III domain-containing protein 3A

Source gene: FNDC3A

Class: DEG_COP1_1

Location: 296:305

E3 ligase: COP1

DEGRON score: 0.9971

ASA_SCORE: 66.53

COIL: 0.8394

CONS_SCORE: 0.268

DSS_SCORE: 0.3779

HELIX: 0.0207

FCONS_SCORE: 0.5784

RIG_SCORE: 0.7551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L311M	TCGA-B5-A1MR	UCEC	TCGA	ETDESSVPEL	DEG_COP1_1	0.1667
p.L311M	DO41758	UCEC	ICGC	ETDESSVPEL	DEG_COP1_1	0.1667
p.P303Q	TCGA-D3-A2JP	SKCM	TCGA	ETDESSVPEL	DEG_COP1_1	0.7035
p.P303Q	DO47407	SKCM	ICGC	ETDESSVPEL	DEG_COP1_1	0.7035
p.G295C	SIDM01951	Colorectal Carcinoma	GDSC	ETDESSVPEL	DEG_COP1_1	0.3056
p.S314G	SIDM01113	Other Sarcomas	GDSC	ETDESSVPEL	DEG_COP1_1	0.0833
p.S314G	SK-UT-1	soft_tissue	COSMIC	ETDESSVPEL	DEG_COP1_1	0.0833
p.E309A	SIDM01588	Endometrial Carcinoma	GDSC	ETDESSVPEL	DEG_COP1_1	0.2222
p.E309A	ACH-000993	Endometrial/Uterine Cancer	CCLE	ETDESSVPEL	DEG_COP1_1	0.2222
p.Y306C	ACH-001656	Leukemia	CCLE	ETDESSVPEL	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	DEG_COP1_1	296:305	ETDESSVPEL	COP1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons