DegronMD

Uniprot ID: O94929

Source protein: Actin-binding LIM protein 3

Source gene: ABLIM3

Class: DEG_SPOP_SBC_1

Location: 417:421

E3 ligase: SPOP

DEGRON score: 0.9974

ASA_SCORE: 90.76

COIL: 0.9408

CONS_SCORE: 0.2793

DSS_SCORE: 0.6283

HELIX: 0.032

FCONS_SCORE: 1.2191

RIG_SCORE: 0.6256

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P410T	TCGA-97-8176	LUAD	TCGA	VRSST	DEG_SPOP_SBC_1	0.1389
p.P410T	DO218933	LUAD	ICGC	VRSST	DEG_SPOP_SBC_1	0.1389
p.R407Q	TCGA-EE-A2M5	SKCM	TCGA	VRSST	DEG_SPOP_SBC_1	0.0556
p.R407Q	DO222423	MELA	ICGC	VRSST	DEG_SPOP_SBC_1	0.0556
p.R407Q	DO37425	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	0.0556
p.S420C	TCGA-GS-A9TW	DLBC	TCGA	VRSST	DEG_SPOP_SBC_1	0.7541
p.S420C	DO219915	DLBC	ICGC	VRSST	DEG_SPOP_SBC_1	0.7541
p.P410S	TCGA-IH-A3EA	SKCM	TCGA	VRSST	DEG_SPOP_SBC_1	0.1389
p.P410S	DO37667	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	0.1389
p.Y411C	DO222503	COCA	ICGC	VRSST	DEG_SPOP_SBC_1	0.6111
p.R407W	DO233767	GACA	ICGC	VRSST	DEG_SPOP_SBC_1	0.0556
p.S408L	DO233820	GACA	ICGC	VRSST	DEG_SPOP_SBC_1	0.0833
p.H412R	DO228909	LICA	ICGC	VRSST	DEG_SPOP_SBC_1	0.1944
p.M420I	DO24606	LUAD	ICGC	VRSST	DEG_SPOP_SBC_1	0.7618
p.H417Y	DO42713	UCEC	ICGC	VRSST	DEG_SPOP_SBC_1	0.7229
p.S419A	ACH-001991	Primary	CCLE	VRSST	DEG_SPOP_SBC_1	0.7588
p.P412L	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VRSST	DEG_SPOP_SBC_1	0.1944
p.R409W	NCI-SNU-1	stomach	COSMIC	VRSST	DEG_SPOP_SBC_1	0.5556
p.R423W	NCI-H1048	lung	COSMIC	VRSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75976	Carboxypeptidase D	DEG_SPOP_SBC_1	871:875	VRSST	SPOP	0.9797	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	417:421	VRSST	SPOP	0.9974	More...
P32019	Type II inositol 1,4,5-trisphosphate 5-phosphatase	DEG_SPOP_SBC_1	302:306	VRSST	SPOP	0.9691	More...
Q8NEQ6	Steroid receptor-associated and regulated protein	DEG_SPOP_SBC_1	145:149	VRSST	SPOP	0.9865	More...
Q14CZ0	Telomere attrition and p53 response 1 protein	DEG_SPOP_SBC_1	205:209	VRSST	SPOP	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons