DegronMD

Uniprot ID: P32019

Source protein: Type II inositol 1,4,5-trisphosphate 5-phosphatase

Source gene: INPP5B

Class: DEG_SPOP_SBC_1

Location: 302:306

E3 ligase: SPOP

DEGRON score: 0.9691

ASA_SCORE: 71.2

COIL: 0.6568

CONS_SCORE: 0.2474

DSS_SCORE: 0.4667

HELIX: 0.3152

FCONS_SCORE: 1.0483

RIG_SCORE: 0.7364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q292H	TCGA-17-Z016	LUAD	TCGA	VRSST	DEG_SPOP_SBC_1	0.0556
p.T316I	TCGA-DF-A2KU	UCEC	TCGA	VRSST	DEG_SPOP_SBC_1	0.0556
p.Q309P	DO9876	COAD	ICGC	VRSST	DEG_SPOP_SBC_1	0.25
p.S304F	DO219892	DLBC	ICGC	VRSST	DEG_SPOP_SBC_1	0.7982
p.H314Y	DO26469	LUSC	ICGC	VRSST	DEG_SPOP_SBC_1	0.1111
p.R303C	DO45482	LUSC	ICGC	VRSST	DEG_SPOP_SBC_1	0.719
p.R303C	DO37703	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	0.719
p.R303C	DO37406	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	0.719
p.S305F	DO38099	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	0.7982
p.R303H	DO41379	UCEC	ICGC	VRSST	DEG_SPOP_SBC_1	0.7133
p.Y297C	SIDM01090	Colorectal Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944
p.Y297C	ACH-000943	Colon/Colorectal Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	0.1944
p.Y297C	RKO	large_intestine	COSMIC	VRSST	DEG_SPOP_SBC_1	0.1944
p.K312T	ACH-000539	Non-Cancerous	CCLE	VRSST	DEG_SPOP_SBC_1	0.6111
p.V296I	ACH-001030	Bone Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	0.1667
p.E302D	HCC2998	large_intestine	COSMIC	VRSST	DEG_SPOP_SBC_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75976	Carboxypeptidase D	DEG_SPOP_SBC_1	871:875	VRSST	SPOP	0.9797	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	417:421	VRSST	SPOP	0.9974	More...
P32019	Type II inositol 1,4,5-trisphosphate 5-phosphatase	DEG_SPOP_SBC_1	302:306	VRSST	SPOP	0.9691	More...
Q8NEQ6	Steroid receptor-associated and regulated protein	DEG_SPOP_SBC_1	145:149	VRSST	SPOP	0.9865	More...
Q14CZ0	Telomere attrition and p53 response 1 protein	DEG_SPOP_SBC_1	205:209	VRSST	SPOP	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons