DegronMD - O75976(CPD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D876Y	TCGA-AA-A010	COAD	TCGA	VRSST	DEG_SPOP_SBC_1	871:875	Mutation rewiring degron network	0.3056
p.D876Y	TCGA-AP-A051	UCEC	TCGA	VRSST	DEG_SPOP_SBC_1	871:875	Mutation rewiring degron network	0.3056
p.Q865H	TCGA-EE-A29W	SKCM	TCGA	VRSST	DEG_SPOP_SBC_1	871:875	Mutation rewiring degron network	0.1667
p.L870F	TCGA-EY-A1GU	UCEC	TCGA	VRSST	DEG_SPOP_SBC_1	871:875	Mutation rewiring degron network	0.3056
p.R872L	TCGA-KR-A7K7	LIHC	TCGA	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.7316
p.H883N	DO2401	BRCA	ICGC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation substituting flanking lysine	0.2222
p.N881S	DO11591	GBM	ICGC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation rewiring degron network	0.1667
p.A880S	DO229015	LICA	ICGC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation rewiring degron network	0.1944
p.L878F	DO47256	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation rewiring degron network	0.25
p.H874N	DO229229	THCA	ICGC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.7423
p.T871I	DO43755	UCEC	ICGC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.7078
p.R872Q	SIDM00596	Endometrial Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.6218
p.R872Q	SIDM00118	Colorectal Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.6218
p.R872Q	ACH-000941	Endometrial/Uterine Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.6218
p.R872Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.6218
p.R872Q	ACH-001081	Colon/Colorectal Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.6218
p.R872Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.6218
p.R872Q	HEC-1	endometrium	COSMIC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.6218
p.R872Q	HCC2998	large intestine	COSMIC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.6218
p.N879S	ACH-000850	Non-Cancerous	CCLE	VRSST	DEG_SPOP_SBC_1	871:875	Mutation rewiring degron network	0.2222
p.H874Y	BHY	upper aerodigestive tract	COSMIC	VRSST	DEG_SPOP_SBC_1	871:875	Mutation altering degron motif	0.7229

Kaplan plot for CPD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPD

UniProt ID: O75976

Entrez ID: 1362

Protein name: Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPD in