DegronMD

Uniprot ID: O75976

Source protein: Carboxypeptidase D

Source gene: CPD

Class: DEG_SPOP_SBC_1

Location: 871:875

E3 ligase: SPOP

DEGRON score: 0.9797

ASA_SCORE: 58.52

COIL: 0.8018

CONS_SCORE: 0.404

DSS_SCORE: 0.4788

HELIX: 0.0502

FCONS_SCORE: 0.9932

RIG_SCORE: 0.7458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D876Y	TCGA-AA-A010	COAD	TCGA	VRSST	DEG_SPOP_SBC_1	0.3056
p.D876Y	TCGA-AP-A051	UCEC	TCGA	VRSST	DEG_SPOP_SBC_1	0.3056
p.Q865H	TCGA-EE-A29W	SKCM	TCGA	VRSST	DEG_SPOP_SBC_1	0.1667
p.L870F	TCGA-EY-A1GU	UCEC	TCGA	VRSST	DEG_SPOP_SBC_1	0.3056
p.R872L	TCGA-KR-A7K7	LIHC	TCGA	VRSST	DEG_SPOP_SBC_1	0.7316
p.H883N	DO2401	BRCA	ICGC	VRSST	DEG_SPOP_SBC_1	0.2222
p.N881S	DO11591	GBM	ICGC	VRSST	DEG_SPOP_SBC_1	0.1667
p.A880S	DO229015	LICA	ICGC	VRSST	DEG_SPOP_SBC_1	0.1944
p.L878F	DO47256	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	0.25
p.H874N	DO229229	THCA	ICGC	VRSST	DEG_SPOP_SBC_1	0.7423
p.T871I	DO43755	UCEC	ICGC	VRSST	DEG_SPOP_SBC_1	0.7078
p.R872Q	SIDM00596	Endometrial Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.6218
p.R872Q	SIDM00118	Colorectal Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.6218
p.R872Q	ACH-000941	Endometrial/Uterine Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	0.6218
p.R872Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	0.6218
p.R872Q	ACH-001081	Colon/Colorectal Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	0.6218
p.R872Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	0.6218
p.R872Q	HEC-1	endometrium	COSMIC	VRSST	DEG_SPOP_SBC_1	0.6218
p.R872Q	HCC2998	large_intestine	COSMIC	VRSST	DEG_SPOP_SBC_1	0.6218
p.N879S	ACH-000850	Non-Cancerous	CCLE	VRSST	DEG_SPOP_SBC_1	0.2222
p.H874Y	BHY	upper_aerodigestive_tract	COSMIC	VRSST	DEG_SPOP_SBC_1	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75976	Carboxypeptidase D	DEG_SPOP_SBC_1	871:875	VRSST	SPOP	0.9797	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	417:421	VRSST	SPOP	0.9974	More...
P32019	Type II inositol 1,4,5-trisphosphate 5-phosphatase	DEG_SPOP_SBC_1	302:306	VRSST	SPOP	0.9691	More...
Q8NEQ6	Steroid receptor-associated and regulated protein	DEG_SPOP_SBC_1	145:149	VRSST	SPOP	0.9865	More...
Q14CZ0	Telomere attrition and p53 response 1 protein	DEG_SPOP_SBC_1	205:209	VRSST	SPOP	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons