DegronMD

Uniprot ID: Q8NEQ6

Source protein: Steroid receptor-associated and regulated protein

Source gene: SRARP

Class: DEG_SPOP_SBC_1

Location: 145:149

E3 ligase: SPOP

DEGRON score: 0.9865

ASA_SCORE: 79.38

COIL: 0.7942

CONS_SCORE: 0.5367

DSS_SCORE: 0.4171

HELIX: 0.146

FCONS_SCORE: 0.8463

RIG_SCORE: 0.7253

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G151V	SIDM00260	Gastric Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.2778
p.G151V	SIDM00248	Gastric Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.2778
p.G151V	MKN28	stomach	COSMIC	VRSST	DEG_SPOP_SBC_1	0.2778
p.V140M	SIDM00556	Neuroblastoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944
p.V140M	SIDM01659	Kidney Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944
p.V140M	SIDM01569	Hepatocellular Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944
p.V140M	SIDM00169	Head and Neck Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944
p.V140M	SIDM01336	Glioblastoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944
p.V140M	SIDM00166	Other Solid Cancers	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944
p.V140M	SIDM01494	Glioblastoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944
p.V140M	SIDM00171	Colorectal Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75976	Carboxypeptidase D	DEG_SPOP_SBC_1	871:875	VRSST	SPOP	0.9797	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	417:421	VRSST	SPOP	0.9974	More...
P32019	Type II inositol 1,4,5-trisphosphate 5-phosphatase	DEG_SPOP_SBC_1	302:306	VRSST	SPOP	0.9691	More...
Q8NEQ6	Steroid receptor-associated and regulated protein	DEG_SPOP_SBC_1	145:149	VRSST	SPOP	0.9865	More...
Q14CZ0	Telomere attrition and p53 response 1 protein	DEG_SPOP_SBC_1	205:209	VRSST	SPOP	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons