DegronMD

Uniprot ID: Q14CZ0

Source protein: Telomere attrition and p53 response 1 protein

Source gene: TAPR1

Class: DEG_SPOP_SBC_1

Location: 205:209

E3 ligase: SPOP

DEGRON score: 0.9684

ASA_SCORE: 84.88

COIL: 0.9

CONS_SCORE: 0.4718

DSS_SCORE: 0.5694

HELIX: 0.0226

FCONS_SCORE: 1.1545

RIG_SCORE: 0.5954

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S207L	DO228542	GACA	ICGC	VRSST	DEG_SPOP_SBC_1	0.7667
p.S204R	ACH-001061	Colon/Colorectal Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	0.75
p.R206C	TCGA-AP-A1DK	UCEC	TCGA	VRSST	DEG_SPOP_SBC_1	0.719
p.R206C	DO42033	UCEC	ICGC	VRSST	DEG_SPOP_SBC_1	0.719
p.R206H	DO52436	COCA	ICGC	VRSST	DEG_SPOP_SBC_1	0.7133
p.P210A	DO231043	LUSC	ICGC	VRSST	DEG_SPOP_SBC_1	0.3056
p.P210T	SIDM01017	B-Lymphoblastic Leukemia	GDSC	VRSST	DEG_SPOP_SBC_1	0.3056
p.P210T	ACH-002255	Lymphoma	CCLE	VRSST	DEG_SPOP_SBC_1	0.3056
p.M200T	TCGA-F4-6703	COAD	TCGA	VRSST	DEG_SPOP_SBC_1	0.1944
p.M200T	DO9908	COAD	ICGC	VRSST	DEG_SPOP_SBC_1	0.1944
p.H215Y	TCGA-CQ-A4CD	HNSC	TCGA	VRSST	DEG_SPOP_SBC_1	0.1667
p.H215Y	DO49038	HNSC	ICGC	VRSST	DEG_SPOP_SBC_1	0.1667
p.V216L	TCGA-29-2434	OV	TCGA	VRSST	DEG_SPOP_SBC_1	0.1389
p.V216L	DO31360	OV	ICGC	VRSST	DEG_SPOP_SBC_1	0.1389
p.G198D	TCGA-DK-A3IN	BLCA	TCGA	VRSST	DEG_SPOP_SBC_1	0.1389
p.G198D	DO455	BLCA	ICGC	VRSST	DEG_SPOP_SBC_1	0.1389
p.V216I	ACH-000773	Lymphoma	CCLE	VRSST	DEG_SPOP_SBC_1	0.1389
p.G195C	TCGA-EE-A2MG	SKCM	TCGA	VRSST	DEG_SPOP_SBC_1	0.0556
p.G195C	DO37421	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	417:421	VRSST	SPOP	0.9974	More...
O75976	Carboxypeptidase D	DEG_SPOP_SBC_1	871:875	VRSST	SPOP	0.9797	More...
Q8NEQ6	Steroid receptor-associated and regulated protein	DEG_SPOP_SBC_1	145:149	VRSST	SPOP	0.9865	More...
Q14CZ0	Telomere attrition and p53 response 1 protein	DEG_SPOP_SBC_1	205:209	VRSST	SPOP	0.9684	More...
P32019	Type II inositol 1,4,5-trisphosphate 5-phosphatase	DEG_SPOP_SBC_1	302:306	VRSST	SPOP	0.9691	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons