DegronMD - Q14CZ0(TAPR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V216L	TCGA-29-2434	OV	TCGA	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1389
p.V216L	DO31360	OV	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1389
p.R206C	TCGA-AP-A1DK	UCEC	TCGA	VRSST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.719
p.R206C	DO42033	UCEC	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.719
p.H215Y	TCGA-CQ-A4CD	HNSC	TCGA	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1667
p.H215Y	DO49038	HNSC	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1667
p.G198D	TCGA-DK-A3IN	BLCA	TCGA	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1389
p.G198D	DO455	BLCA	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1389
p.G195C	TCGA-EE-A2MG	SKCM	TCGA	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0556
p.G195C	DO37421	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0556
p.M200T	TCGA-F4-6703	COAD	TCGA	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.M200T	DO9908	COAD	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.R206H	DO52436	COCA	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.7133
p.S207L	DO228542	GACA	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.7667
p.P210A	DO231043	LUSC	ICGC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.P210T	SIDM01017	B-Lymphoblastic Leukemia	GDSC	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.P210T	ACH-002255	Lymphoma	CCLE	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.V216I	ACH-000773	Lymphoma	CCLE	VRSST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1389
p.S204R	ACH-001061	Colon/Colorectal Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	205:209	Mutation blocking phosphorylation signal	0.75

Kaplan plot for TAPR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAPR1

UniProt ID: Q14CZ0

Entrez ID: 29035

Protein name: Telomere attrition and p53 response 1 protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAPR1 in