DegronMD - P32019(INPP5B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q292H	TCGA-17-Z016	LUAD	TCGA	VRSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.0556
p.T316I	TCGA-DF-A2KU	UCEC	TCGA	VRSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.0556
p.Q309P	DO9876	COAD	ICGC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.S304F	DO219892	DLBC	ICGC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7982
p.H314Y	DO26469	LUSC	ICGC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1111
p.R303C	DO45482	LUSC	ICGC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.719
p.R303C	DO37703	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.719
p.R303C	DO37406	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.719
p.S305F	DO38099	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7982
p.R303H	DO41379	UCEC	ICGC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7133
p.Y297C	SIDM01090	Colorectal Carcinoma	GDSC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1944
p.Y297C	ACH-000943	Colon/Colorectal Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1944
p.Y297C	RKO	large intestine	COSMIC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1944
p.K312T	ACH-000539	Non-Cancerous	CCLE	VRSST	DEG_SPOP_SBC_1	302:306	Mutation blocking ubiquitination signal	0.6111
p.V296I	ACH-001030	Bone Cancer	CCLE	VRSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1667
p.E302D	HCC2998	large intestine	COSMIC	VRSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.6758

Kaplan plot for INPP5B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INPP5B

UniProt ID: P32019

Entrez ID: 3633

Protein name: Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INPP5B in