DegronMD

Uniprot ID: Q96KW2

Source protein: POM121-like protein 2

Source gene: POM121L2

Class: DEG_SPOP_SBC_1

Location: 623:627

E3 ligase: SPOP

DEGRON score: 0.5294

ASA_SCORE: 90.26

COIL: 0.8342

CONS_SCORE: 0.5962

DSS_SCORE: 0.2531

HELIX: 0.0212

FCONS_SCORE: 0.7442

RIG_SCORE: 0.7975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A629G	TCGA-17-Z033	LUAD	TCGA	VMSTT	DEG_SPOP_SBC_1	0.2778
p.D634Y	TCGA-A5-A2K5	UCEC	TCGA	VMSTT	DEG_SPOP_SBC_1	0.1389
p.D634Y	DO41379	UCEC	ICGC	VMSTT	DEG_SPOP_SBC_1	0.1389
p.S635Y	TCGA-AA-A010	COAD	TCGA	VMSTT	DEG_SPOP_SBC_1	0.1111
p.T626N	TCGA-RG-A7D4	LIHC	TCGA	VMSTT	DEG_SPOP_SBC_1	0.7055
p.T626N	DO52316	LIHC	ICGC	VMSTT	DEG_SPOP_SBC_1	0.7055
p.M624I	DO222817	BTCA	ICGC	VMSTT	DEG_SPOP_SBC_1	0.6507
p.S621F	DO233098	GACA	ICGC	VMSTT	DEG_SPOP_SBC_1	0.2778
p.T620N	DO23344	LINC	ICGC	VMSTT	DEG_SPOP_SBC_1	0.25
p.G615N	DO222632	MELA	ICGC	VMSTT	DEG_SPOP_SBC_1	0.1111
p.G615D	DO232761	PBCA	ICGC	VMSTT	DEG_SPOP_SBC_1	0.1111
p.V622L	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	VMSTT	DEG_SPOP_SBC_1	0.3056
p.V622L	ACH-000521	Lung Cancer	CCLE	VMSTT	DEG_SPOP_SBC_1	0.3056
p.V622L	NCI-H2030	lung	COSMIC	VMSTT	DEG_SPOP_SBC_1	0.3056
p.F613L	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	VMSTT	DEG_SPOP_SBC_1	0.0556
p.F613L	ACH-000733	Lung Cancer	CCLE	VMSTT	DEG_SPOP_SBC_1	0.0556
p.F613L	NCI-H1838	lung	COSMIC	VMSTT	DEG_SPOP_SBC_1	0.0556
p.V617L	SIDM01039	Other Solid Cancers	GDSC	VMSTT	DEG_SPOP_SBC_1	0.1667
p.V617L	JAR	placenta	COSMIC	VMSTT	DEG_SPOP_SBC_1	0.1667
p.V623I	SIDM00422	Hodgkin's Lymphoma	GDSC	VMSTT	DEG_SPOP_SBC_1	0.7076
p.V623I	ACH-001203	Lymphoma	CCLE	VMSTT	DEG_SPOP_SBC_1	0.7076
p.V623I	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VMSTT	DEG_SPOP_SBC_1	0.7076

DegronMD: protein-targeted degradation, mutation and drug response to degrons