DegronMD

Uniprot ID: Q6QHK4

Source protein: Factor in the germline alpha

Source gene: FIGLA

Class: DEG_SPOP_SBC_1

Location: 190:194

E3 ligase: SPOP

DEGRON score: 0.9664

ASA_SCORE: 78.78

COIL: 0.7442

CONS_SCORE: 0.2776

DSS_SCORE: 0.4615

HELIX: 0.0636

FCONS_SCORE: 0.8853

RIG_SCORE: 0.7072

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G180V	TCGA-44-7670	LUAD	TCGA	VMSTT	DEG_SPOP_SBC_1	0.0556
p.G180V	DO23555	LUAD	ICGC	VMSTT	DEG_SPOP_SBC_1	0.0556
p.S189N	TCGA-51-6867	LUSC	TCGA	VMSTT	DEG_SPOP_SBC_1	0.3056
p.S189N	DO26477	LUSC	ICGC	VMSTT	DEG_SPOP_SBC_1	0.3056
p.R201I	TCGA-AP-A1E0	UCEC	TCGA	VMSTT	DEG_SPOP_SBC_1	0.1389
p.R201I	DO43154	UCEC	ICGC	VMSTT	DEG_SPOP_SBC_1	0.1389
p.H188R	TCGA-CG-5726	STAD	TCGA	VMSTT	DEG_SPOP_SBC_1	0.2778
p.H188R	DO38483	STAD	ICGC	VMSTT	DEG_SPOP_SBC_1	0.2778
p.I196F	TCGA-DX-AB32	SARC	TCGA	VMSTT	DEG_SPOP_SBC_1	0.2778
p.I196F	DO220102	SARC	ICGC	VMSTT	DEG_SPOP_SBC_1	0.2778
p.H188Q	TCGA-MP-A4TI	LUAD	TCGA	VMSTT	DEG_SPOP_SBC_1	0.2778
p.H188Q	DO45420	LUAD	ICGC	VMSTT	DEG_SPOP_SBC_1	0.2778
p.S192Y	DO232826	NACA	ICGC	VMSTT	DEG_SPOP_SBC_1	0.712
p.A185P	DO233292	NACA	ICGC	VMSTT	DEG_SPOP_SBC_1	0.1944
p.A183T	DO71709	THCA	ICGC	VMSTT	DEG_SPOP_SBC_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons