DegronMD - Q6QHK4(FIGLA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G180V	TCGA-44-7670	LUAD	TCGA	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.G180V	DO23555	LUAD	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.S189N	TCGA-51-6867	LUSC	TCGA	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.S189N	DO26477	LUSC	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.R201I	TCGA-AP-A1E0	UCEC	TCGA	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1389
p.R201I	DO43154	UCEC	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1389
p.A13V	TCGA-AY-A69D	COAD	TCGA	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation rewiring degron network	0.2222
p.A13V	DO49102	COAD	ICGC	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation rewiring degron network	0.2222
p.H188R	TCGA-CG-5726	STAD	TCGA	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.H188R	DO38483	STAD	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.I196F	TCGA-DX-AB32	SARC	TCGA	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.I196F	DO220102	SARC	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.H188Q	TCGA-MP-A4TI	LUAD	TCGA	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.H188Q	DO45420	LUAD	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.V29L	DO50393	ESAD	ICGC	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation rewiring degron network	0.1944
p.V7I	DO228257	MALY	ICGC	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation rewiring degron network	0.0556
p.S192Y	DO232826	NACA	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.712
p.A185P	DO233292	NACA	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1944
p.P21R	DO229259	THCA	ICGC	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation altering degron motif	0.7512
p.A183T	DO71709	THCA	ICGC	VMSTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1389
p.R11C	SIDM01943	Colorectal Carcinoma	GDSC	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation rewiring degron network	0.1667
p.L18V	ACH-000890	Lung Cancer	CCLE	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation altering degron motif	0.5654
p.P10H	ACH-001396	Metastasis	CCLE	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation rewiring degron network	0.1389
p.A13T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation rewiring degron network	0.2222
p.G19D	ACH-001991	Primary	CCLE	LLGTPQAE	DEG_SCF_FBW7_2	17:24	Mutation altering degron motif	0.6087

Kaplan plot for FIGLA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FIGLA

UniProt ID: Q6QHK4

Entrez ID: 344018

Protein name: Factor in the germline alpha (FIGalpha) (Class C basic helix-loop-helix protein 8) (bHLHc8) (Folliculogenesis-specific basic helix-loop-helix protein) (Transcription factor FIGa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FIGLA in