DegronMD

Uniprot ID: Q6QHK4

Source protein: Factor in the germline alpha

Source gene: FIGLA

Class: DEG_SCF_FBW7_2

Location: 17:24

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 72.1625

COIL: 0.7603

CONS_SCORE: 0.4407

DSS_SCORE: 0.4282

HELIX: 0.2143

FCONS_SCORE: 1.2017

RIG_SCORE: 0.714

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P21R	DO229259	THCA	ICGC	LLGTPQAE	DEG_SCF_FBW7_2	0.7512
p.G19D	ACH-001991	Primary	CCLE	LLGTPQAE	DEG_SCF_FBW7_2	0.6087
p.L18V	ACH-000890	Lung Cancer	CCLE	LLGTPQAE	DEG_SCF_FBW7_2	0.5654
p.A13V	TCGA-AY-A69D	COAD	TCGA	LLGTPQAE	DEG_SCF_FBW7_2	0.2222
p.A13V	DO49102	COAD	ICGC	LLGTPQAE	DEG_SCF_FBW7_2	0.2222
p.A13T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LLGTPQAE	DEG_SCF_FBW7_2	0.2222
p.V29L	DO50393	ESAD	ICGC	LLGTPQAE	DEG_SCF_FBW7_2	0.1944
p.R11C	SIDM01943	Colorectal Carcinoma	GDSC	LLGTPQAE	DEG_SCF_FBW7_2	0.1667
p.P10H	ACH-001396	Metastasis	CCLE	LLGTPQAE	DEG_SCF_FBW7_2	0.1389
p.V7I	DO228257	MALY	ICGC	LLGTPQAE	DEG_SCF_FBW7_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6QHK4	Factor in the germline alpha	DEG_SCF_FBW7_2	17:24	LLGTPQAE	FBXW7	0.9946	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons