DegronMD

Uniprot ID: Q96KW2

Source protein: POM121-like protein 2

Source gene: POM121L2

Class: DEG_SCF_FBW7_1

Location: 739:746

E3 ligase: FBXW7

DEGRON score: 0.9626

ASA_SCORE: 74.8375

COIL: 0.9163

CONS_SCORE: 0.6473

DSS_SCORE: 0.3218

HELIX: 0.0416

FCONS_SCORE: 1.1221

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P755T	TCGA-AX-A2HC	UCEC	TCGA	LASTPSIS	DEG_SCF_FBW7_1	0.0833
p.P755T	DO41572	UCEC	ICGC	LASTPSIS	DEG_SCF_FBW7_1	0.0833
p.S744C	DO233834	GACA	ICGC	LASTPSIS	DEG_SCF_FBW7_1	0.643
p.A730T	DO14232	HNSC	ICGC	LASTPSIS	DEG_SCF_FBW7_1	0.0833
p.W738L	DO50931	LICA	ICGC	LASTPSIS	DEG_SCF_FBW7_1	0.3056
p.P755L	DO220889	MELA	ICGC	LASTPSIS	DEG_SCF_FBW7_1	0.0833
p.P755L	DO222595	MELA	ICGC	LASTPSIS	DEG_SCF_FBW7_1	0.0833
p.N737I	SIDM00999	Bladder Carcinoma	GDSC	LASTPSIS	DEG_SCF_FBW7_1	0.2778
p.N737I	639-V	urinary_tract	COSMIC	LASTPSIS	DEG_SCF_FBW7_1	0.2778
p.T742A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LASTPSIS	DEG_SCF_FBW7_1	0.7139
p.T742A	ACH-001127	Leukemia	CCLE	LASTPSIS	DEG_SCF_FBW7_1	0.7139
p.T742A	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LASTPSIS	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KW2	POM121-like protein 2	DEG_SCF_FBW7_1	739:746	LASTPSIS	FBXW7	0.9626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons