DegronMD

Uniprot ID: Q96KW2

Source protein: POM121-like protein 2

Source gene: POM121L2

Class: DEG_SCF_FBW7_1

Location: 831:836

E3 ligase: FBXW7

DEGRON score: 0.9952

ASA_SCORE: 72.8833

COIL: 0.8823

CONS_SCORE: 0.8677

DSS_SCORE: 0.4858

HELIX: 0.0287

FCONS_SCORE: 1.1647

RIG_SCORE: 0.7005

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A827P	DO46992	RECA	ICGC	LTPSAS	DEG_SCF_FBW7_1	0.2222
p.T824A	SIDM00650	Small Cell Lung Carcinoma	GDSC	LTPSAS	DEG_SCF_FBW7_1	0.1389
p.T824A	SIDM01681	Non-Cancerous	GDSC	LTPSAS	DEG_SCF_FBW7_1	0.1389
p.T824A	SIDM00785	Acute Myeloid Leukemia	GDSC	LTPSAS	DEG_SCF_FBW7_1	0.1389
p.T844I	ACH-001413	Bladder Cancer	CCLE	LTPSAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06576	ATP synthase subunit beta, mitochondrial	DEG_SCF_FBW7_1	20:25	LTPSAS	FBXW7	0.9994	More...
Q8N4C6	Ninein	DEG_SCF_FBW7_1	253:258	LTPSAS	FBXW7	0.9937	More...
Q96KW2	POM121-like protein 2	DEG_SCF_FBW7_1	831:836	LTPSAS	FBXW7	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons