DegronMD

Uniprot ID: Q8N4C6

Source protein: Ninein

Source gene: NIN

Class: DEG_SCF_FBW7_1

Location: 253:258

E3 ligase: FBXW7

DEGRON score: 0.9937

ASA_SCORE: 66.7833

COIL: 0.9117

CONS_SCORE: 0.7188

DSS_SCORE: 0.4339

HELIX: 0.0467

FCONS_SCORE: 1.0348

RIG_SCORE: 0.6847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T259S	TCGA-BR-7704	STAD	TCGA	LTPSAS	DEG_SCF_FBW7_1	0.75
p.T259S	DO38360	STAD	ICGC	LTPSAS	DEG_SCF_FBW7_1	0.75
p.F243L	TCGA-CA-6718	COAD	TCGA	LTPSAS	DEG_SCF_FBW7_1	0.0556
p.F243L	DO7801	COAD	ICGC	LTPSAS	DEG_SCF_FBW7_1	0.0556
p.L253I	TCGA-D3-A2JP	SKCM	TCGA	LTPSAS	DEG_SCF_FBW7_1	0.6063
p.L253I	DO47407	SKCM	ICGC	LTPSAS	DEG_SCF_FBW7_1	0.6063
p.L253F	TCGA-EO-A22U	UCEC	TCGA	LTPSAS	DEG_SCF_FBW7_1	0.6981
p.L253F	DO43755	UCEC	ICGC	LTPSAS	DEG_SCF_FBW7_1	0.6981
p.F243I	DO234197	ESAD	ICGC	LTPSAS	DEG_SCF_FBW7_1	0.0556
p.P255T	DO229028	LICA	ICGC	LTPSAS	DEG_SCF_FBW7_1	0.7031
p.P255T	DO229045	LICA	ICGC	LTPSAS	DEG_SCF_FBW7_1	0.7031
p.K265R	SIDM00333	Endometrial Carcinoma	GDSC	LTPSAS	DEG_SCF_FBW7_1	0.25
p.K265R	ACH-000988	Endometrial/Uterine Cancer	CCLE	LTPSAS	DEG_SCF_FBW7_1	0.25
p.K265R	MFE-319	endometrium	COSMIC	LTPSAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06576	ATP synthase subunit beta, mitochondrial	DEG_SCF_FBW7_1	20:25	LTPSAS	FBXW7	0.9994	More...
Q8N4C6	Ninein	DEG_SCF_FBW7_1	253:258	LTPSAS	FBXW7	0.9937	More...
Q96KW2	POM121-like protein 2	DEG_SCF_FBW7_1	831:836	LTPSAS	FBXW7	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons