DegronMD

Uniprot ID: P06576

Source protein: ATP synthase subunit beta, mitochondrial

Source gene: ATP5F1B

Class: DEG_SCF_FBW7_1

Location: 20:25

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 75.6833

COIL: 0.864

CONS_SCORE: 0.2282

DSS_SCORE: 0.3649

HELIX: 0.1022

FCONS_SCORE: 1.058

RIG_SCORE: 0.7186

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S25L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	LTPSAS	DEG_SCF_FBW7_1	0.8778
p.S25L	SIDM00365	Small Cell Lung Carcinoma	GDSC	LTPSAS	DEG_SCF_FBW7_1	0.8778
p.S25L	SIDM00316	Glioblastoma	GDSC	LTPSAS	DEG_SCF_FBW7_1	0.8778

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06576	ATP synthase subunit beta, mitochondrial	DEG_SCF_FBW7_1	20:25	LTPSAS	FBXW7	0.9994	More...
Q8N4C6	Ninein	DEG_SCF_FBW7_1	253:258	LTPSAS	FBXW7	0.9937	More...
Q96KW2	POM121-like protein 2	DEG_SCF_FBW7_1	831:836	LTPSAS	FBXW7	0.9952	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons