DegronMD - Q8N4C6(NIN)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1141W	TCGA-A5-A0G2	UCEC	TCGA	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.8634
p.R1141W	TCGA-HU-A4GT	STAD	TCGA	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.8634
p.R1141W	DO48020	STAD	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.8634
p.R1141W	DO41235	UCEC	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.8634
p.T259S	TCGA-BR-7704	STAD	TCGA	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation blocking phosphorylation signal	0.75
p.T259S	DO38360	STAD	ICGC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation blocking phosphorylation signal	0.75
p.R1141Q	TCGA-BS-A0UM	UCEC	TCGA	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.7329
p.R1141Q	DO233747	GACA	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.7329
p.R1141Q	DO43065	UCEC	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.7329
p.F243L	TCGA-CA-6718	COAD	TCGA	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.0556
p.F243L	DO7801	COAD	ICGC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.0556
p.L253I	TCGA-D3-A2JP	SKCM	TCGA	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.6063
p.L253I	DO47407	SKCM	ICGC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.6063
p.E1151A	TCGA-D9-A6EC	SKCM	TCGA	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.25
p.E1151A	DO50291	SKCM	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.25
p.Q1134L	TCGA-DD-AADF	LIHC	TCGA	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.1667
p.Q1134L	DO52232	LIHC	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.1667
p.L253F	TCGA-EO-A22U	UCEC	TCGA	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.6981
p.L253F	DO43755	UCEC	ICGC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.6981
p.T1132M	TCGA-HU-A4G8	STAD	TCGA	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.1111
p.T1132M	DO47819	STAD	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.1111
p.D1150H	TCGA-XF-A9SI	BLCA	TCGA	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.2778
p.D1150H	DO51914	BLCA	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.2778
p.L833V	TCGA-ZF-AA54	BLCA	TCGA	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.1389
p.L833V	DO219098	BLCA	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.1389
p.E840Q	DO49020	CESC	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.6744
p.T845M	DO7977	COAD	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.7423
p.T845M	DO46657	PAAD	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.7423
p.T845M	HCT-116	large intestine	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.7423
p.T845M	CAL-78	bone	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.7423
p.L1139I	DO9876	COAD	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.3056
p.F243I	DO234197	ESAD	ICGC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.0556
p.R841H	DO233202	GACA	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.8244
p.N1130K	DO229028	LICA	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.0556
p.P255T	DO229028	LICA	ICGC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.7031
p.P255T	DO229045	LICA	ICGC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.7031
p.Q850K	DO229036	LICA	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.2778
p.D846E	DO229038	LICA	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.5647
p.E846K	DO28012	OV	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.7022
p.L834V	DO43202	UCEC	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.1667
p.L1146P	DO41871	UCEC	ICGC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.7582
p.V1152F	SIDM00773	Non-Cancerous	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.2222
p.V1152F	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.2222
p.V1152F	SIDM00907	Burkitt's Lymphoma	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.2222
p.V1152F	SIDM00863	Burkitt's Lymphoma	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.2222
p.V1152F	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.2222
p.V1152F	SIDM01173	Rhabdomyosarcoma	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.2222
p.K265R	SIDM00333	Endometrial Carcinoma	GDSC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation substituting flanking lysine	0.25
p.K265R	ACH-000988	Endometrial/Uterine Cancer	CCLE	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation substituting flanking lysine	0.25
p.K265R	MFE-319	endometrium	COSMIC	LTPSAS	DEG_SCF_FBW7_1	253:258	Mutation substituting flanking lysine	0.25
p.H1142Y	SIDM00931	Thyroid Gland Carcinoma	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.6118
p.H1142Y	CAL-62	thyroid	COSMIC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation altering degron motif	0.6118
p.T1139A	SIDM00217	Colorectal Carcinoma	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.3056
p.T1139A	ACH-000999	Colon/Colorectal Cancer	CCLE	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.3056
p.T1139A	SNU-1040	large intestine	COSMIC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.3056
p.G838E	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.2778
p.G838E	ACH-000869	Lung Cancer	CCLE	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.2778
p.G838E	NCI-H1568	lung	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.2778
p.R839C	SIDM00980	Gastric Carcinoma	GDSC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.3056
p.R839C	ACH-000948	Gastric Cancer	CCLE	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.3056
p.R839C	23132-87	stomach	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.3056
p.D1149Y	SIDM01772	Mesothelioma	GDSC	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.3056
p.D1149Y	ACH-000531	Non-Cancerous	CCLE	RRHVLSDLE	DEG_APCC_DBOX_1	1140:1148	Mutation rewiring degron network	0.3056
p.E839K	KMS-11	haematopoietic and lymphoid tissue	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.3056

Kaplan plot for NIN in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NIN

UniProt ID: Q8N4C6

Entrez ID: 51199

Protein name: Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NIN in