DegronMD

Uniprot ID: Q8N4C6

Source protein: Ninein

Source gene: NIN

Class: DEG_APCC_DBOX_1

Location: 840:848

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.513

ASA_SCORE: 108.6333

COIL: 0.012

CONS_SCORE: 0.5064

DSS_SCORE: 0.4428

HELIX: 0.9884

FCONS_SCORE: 1.0809

RIG_SCORE: 0.7643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L833V	TCGA-ZF-AA54	BLCA	TCGA	YRQELKDLQ	DEG_APCC_DBOX_1	0.1389
p.L833V	DO219098	BLCA	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.1389
p.E840Q	DO49020	CESC	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.6744
p.T845M	DO7977	COAD	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.7423
p.T845M	DO46657	PAAD	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.7423
p.T845M	HCT-116	large_intestine	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	0.7423
p.T845M	CAL-78	bone	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	0.7423
p.R841H	DO233202	GACA	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.8244
p.Q850K	DO229036	LICA	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.2778
p.D846E	DO229038	LICA	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.5647
p.E846K	DO28012	OV	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.7022
p.L834V	DO43202	UCEC	ICGC	YRQELKDLQ	DEG_APCC_DBOX_1	0.1667
p.G838E	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	YRQELKDLQ	DEG_APCC_DBOX_1	0.2778
p.G838E	ACH-000869	Lung Cancer	CCLE	YRQELKDLQ	DEG_APCC_DBOX_1	0.2778
p.G838E	NCI-H1568	lung	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	0.2778
p.R839C	SIDM00980	Gastric Carcinoma	GDSC	YRQELKDLQ	DEG_APCC_DBOX_1	0.3056
p.R839C	ACH-000948	Gastric Cancer	CCLE	YRQELKDLQ	DEG_APCC_DBOX_1	0.3056
p.R839C	23132-87	stomach	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	0.3056
p.E839K	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	YRQELKDLQ	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4C6	Ninein	DEG_APCC_DBOX_1	840:848	YRQELKDLQ	APC,CDC20,FZR1	0.513	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons