DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRHVLSDLE
Uniprot ID:
Q8N4C6
Source protein:
Ninein
Source gene:
NIN
Class:
DEG_APCC_DBOX_1
Location:
1140:1148
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.874
ASA_SCORE:
107.2222
COIL:
0.2808
CONS_SCORE:
0.2803
DSS_SCORE:
0.5027
HELIX:
0.711
FCONS_SCORE:
1.0212
RIG_SCORE:
0.7707
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R1141W
TCGA-A5-A0G2
UCEC
TCGA
RRHVLSDLE
DEG_APCC_DBOX_1
0.8634
p.R1141W
TCGA-HU-A4GT
STAD
TCGA
RRHVLSDLE
DEG_APCC_DBOX_1
0.8634
p.R1141W
DO48020
STAD
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.8634
p.R1141W
DO41235
UCEC
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.8634
p.R1141Q
TCGA-BS-A0UM
UCEC
TCGA
RRHVLSDLE
DEG_APCC_DBOX_1
0.7329
p.R1141Q
DO233747
GACA
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.7329
p.R1141Q
DO43065
UCEC
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.7329
p.E1151A
TCGA-D9-A6EC
SKCM
TCGA
RRHVLSDLE
DEG_APCC_DBOX_1
0.25
p.E1151A
DO50291
SKCM
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.25
p.Q1134L
TCGA-DD-AADF
LIHC
TCGA
RRHVLSDLE
DEG_APCC_DBOX_1
0.1667
p.Q1134L
DO52232
LIHC
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.1667
p.T1132M
TCGA-HU-A4G8
STAD
TCGA
RRHVLSDLE
DEG_APCC_DBOX_1
0.1111
p.T1132M
DO47819
STAD
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.1111
p.D1150H
TCGA-XF-A9SI
BLCA
TCGA
RRHVLSDLE
DEG_APCC_DBOX_1
0.2778
p.D1150H
DO51914
BLCA
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.2778
p.L1139I
DO9876
COAD
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.3056
p.N1130K
DO229028
LICA
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.0556
p.L1146P
DO41871
UCEC
ICGC
RRHVLSDLE
DEG_APCC_DBOX_1
0.7582
p.V1152F
SIDM00773
Non-Cancerous
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.2222
p.V1152F
SIDM01116
Non-Small Cell Lung Carcinoma
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.2222
p.V1152F
SIDM00907
Burkitt's Lymphoma
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.2222
p.V1152F
SIDM00863
Burkitt's Lymphoma
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.2222
p.V1152F
SIDM00956
Esophageal Squamous Cell Carcinoma
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.2222
p.V1152F
SIDM01173
Rhabdomyosarcoma
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.2222
p.H1142Y
SIDM00931
Thyroid Gland Carcinoma
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.6118
p.H1142Y
CAL-62
thyroid
COSMIC
RRHVLSDLE
DEG_APCC_DBOX_1
0.6118
p.T1139A
SIDM00217
Colorectal Carcinoma
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.3056
p.T1139A
ACH-000999
Colon/Colorectal Cancer
CCLE
RRHVLSDLE
DEG_APCC_DBOX_1
0.3056
p.T1139A
SNU-1040
large_intestine
COSMIC
RRHVLSDLE
DEG_APCC_DBOX_1
0.3056
p.D1149Y
SIDM01772
Mesothelioma
GDSC
RRHVLSDLE
DEG_APCC_DBOX_1
0.3056
p.D1149Y
ACH-000531
Non-Cancerous
CCLE
RRHVLSDLE
DEG_APCC_DBOX_1
0.3056
Drug responses associated with NIN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRHVLSDLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N4C6
Ninein
DEG_APCC_DBOX_1
1140:1148
RRHVLSDLE
APC,CDC20,FZR1
0.874
More...