DegronMD

Uniprot ID: Q96KW2

Source protein: POM121-like protein 2

Source gene: POM121L2

Class: DEG_SCF_FBW7_1

Location: 808:814

E3 ligase: FBXW7

DEGRON score: 0.9829

ASA_SCORE: 85.8571

COIL: 0.963

CONS_SCORE: 0.6564

DSS_SCORE: 0.41

HELIX: 0.0079

FCONS_SCORE: 0.8788

RIG_SCORE: 0.6782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S798F	TCGA-A5-A2K5	UCEC	TCGA	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798F	TCGA-E6-A1LX	UCEC	TCGA	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798F	DO41020	UCEC	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798F	DO41379	UCEC	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798C	TCGA-A8-A097	BRCA	TCGA	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798C	DO6240	BRCA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.A805V	TCGA-B5-A1MX	UCEC	TCGA	LPTPMPT	DEG_SCF_FBW7_1	0.25
p.A805V	DO41999	UCEC	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.25
p.S798Y	TCGA-CA-6718	COAD	TCGA	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798Y	TCGA-EO-A3AV	UCEC	TCGA	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798Y	DO7801	COAD	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798Y	DO222762	COCA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798Y	DO220858	MELA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.S798Y	DO52412	UCEC	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.T810A	DO220880	MELA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.7139
p.T810A	DO222702	MELA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	0.7139
p.T824A	SIDM00650	Small Cell Lung Carcinoma	GDSC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.T824A	SIDM01681	Non-Cancerous	GDSC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.T824A	SIDM00785	Acute Myeloid Leukemia	GDSC	LPTPMPT	DEG_SCF_FBW7_1	0.0556
p.A816V	SIDM00282	Colorectal Carcinoma	GDSC	LPTPMPT	DEG_SCF_FBW7_1	0.2778
p.A816V	SIDM00878	Breast Carcinoma	GDSC	LPTPMPT	DEG_SCF_FBW7_1	0.2778
p.P809S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPTPMPT	DEG_SCF_FBW7_1	0.5641
p.P809S	ACH-001638	Lymphoma	CCLE	LPTPMPT	DEG_SCF_FBW7_1	0.5641
p.P809S	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPMPT	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KW2	POM121-like protein 2	DEG_SCF_FBW7_1	808:814	LPTPMPT	FBXW7	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons