DegronMD

Uniprot ID: O60312

Source protein: Phospholipid-transporting ATPase VA

Source gene: ATP10A

Class: DEG_SCF_TRCP1_1

Location: 1333:1339

E3 ligase: BTRC

DEGRON score: 0.5754

ASA_SCORE: 80.6714

COIL: 0.8243

CONS_SCORE: 0.3044

DSS_SCORE: 0.6718

HELIX: 0.1164

FCONS_SCORE: 0.9488

RIG_SCORE: 0.565

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1329C	TCGA-06-0140	GBM	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.2222
p.R1329C	TCGA-AD-5900	COAD	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.2222
p.R1329C	DO8514	COAD	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.2222
p.R1329C	DO44409	GBM	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.2222
p.R1342M	TCGA-33-4586	LUSC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.25
p.R1342M	DO27318	LUSC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.25
p.K1332N	TCGA-AP-A056	UCEC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.3056
p.K1332N	TCGA-BR-8487	STAD	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.3056
p.K1332N	DO47867	STAD	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.3056
p.K1332N	DO43971	UCEC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.3056
p.P1331L	TCGA-B5-A3FC	UCEC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.2778
p.P1331L	DO41871	UCEC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.2778
p.A1326S	TCGA-C4-A0F0	BLCA	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.1389
p.A1326S	DO520	BLCA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.1389
p.F1325V	TCGA-EO-A22U	UCEC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.1111
p.F1325V	DO43755	UCEC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.1111
p.K1345N	TCGA-FU-A3HZ	CESC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.2778
p.K1345N	DO6308	CESC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.2778
p.H1338N	TCGA-X6-A7WA	SARC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.6312
p.H1338N	DO220312	SARC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.6312
p.G1335E	TCGA-XF-AAN0	BLCA	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	0.7199
p.G1335E	DO51941	BLCA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.7199
p.S1334W	DO233235	GACA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.7874
p.E1337K	DO233731	GACA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.591
p.S1334L	DO233903	GACA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.7667
p.S1334L	DO36556	READ	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.7667
p.R1329S	DO229045	LICA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.2222
p.L1330H	DO45139	LIRI	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	0.25
p.E1323D	SIDM00193	Colorectal Carcinoma	GDSC	DSGTEHS	DEG_SCF_TRCP1_1	0.0556
p.E1323D	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGTEHS	DEG_SCF_TRCP1_1	0.0556
p.E1323D	SNU-81	large_intestine	COSMIC	DSGTEHS	DEG_SCF_TRCP1_1	0.0556
p.G1328A	SIDM00875	Breast Carcinoma	GDSC	DSGTEHS	DEG_SCF_TRCP1_1	0.1944
p.G1328A	ACH-000624	Breast Cancer	CCLE	DSGTEHS	DEG_SCF_TRCP1_1	0.1944
p.G1328A	HCC1806	breast	COSMIC	DSGTEHS	DEG_SCF_TRCP1_1	0.1944
p.G1341W	SIDM00959	Acute Myeloid Leukemia	GDSC	DSGTEHS	DEG_SCF_TRCP1_1	0.2778
p.G1341W	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTEHS	DEG_SCF_TRCP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGTEHS

Degron related mutations and impact score

Drug responses associated with ATP10A mutations

All proteins holding degron of DSGTEHS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60312	Phospholipid-transporting ATPase VA	DEG_SCF_TRCP1_1	1333:1339	DSGTEHS	BTRC	0.5754	More...