DegronMD

Uniprot ID: Q7Z570

Source protein: Zinc finger protein 804A

Source gene: ZNF804A

Class: DEG_ODPH_VHL_1

Location: 1024:1036

E3 ligase: VHL

DEGRON score: 0.6534

ASA_SCORE: 76.0077

COIL: 0.7837

CONS_SCORE: 0.5243

DSS_SCORE: 0.1316

HELIX: 0.1298

FCONS_SCORE: 1.1493

RIG_SCORE: 0.8484

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1037S	TCGA-2W-A8YY	CESC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.3056
p.P1037S	DO223732	CESC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.3056
p.P1037S	DO220900	MELA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.3056
p.L1035F	TCGA-38-4626	LUAD	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.587
p.L1035F	DO24447	LUAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.587
p.E1039D	TCGA-AA-3864	COAD	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.25
p.E1039D	DO8490	COAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.25
p.P1037L	TCGA-CN-6992	HNSC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.3056
p.P1037L	DO14606	HNSC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.3056
p.D1042Y	TCGA-D6-8569	HNSC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1667
p.D1042Y	TCGA-NC-A5HK	LUSC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1667
p.D1042Y	DO14454	HNSC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1667
p.D1042Y	DO219191	LUSC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1667
p.G1014D	TCGA-D7-5578	STAD	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.0556
p.G1014D	DO38475	STAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.0556
p.V1018E	TCGA-DD-AADF	LIHC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1667
p.V1018E	DO52232	LIHC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1667
p.A1025T	TCGA-ER-A199	SKCM	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.7139
p.A1025T	DO47395	SKCM	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.7139
p.A1033E	TCGA-EY-A5W2	UCEC	TCGA	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.659
p.A1033E	DO48177	UCEC	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.659
p.F1017C	DO234189	ESAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1389
p.L1034V	DO234426	ESAD	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.5654
p.G1014C	DO233636	GACA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.0556
p.A1020V	DO233797	GACA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.2222
p.N1046Y	DO49136	PACA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.0556
p.A1033V	DO35083	PACA	ICGC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.5825
p.Q1022K	SIDM00230	Small Cell Lung Carcinoma	GDSC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.2778
p.Q1022K	ACH-002145	Lung Cancer	CCLE	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.2778
p.Q1022K	IST-SL2	lung	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.2778
p.I1036M	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.6507
p.I1036M	ACH-000841	Lung Cancer	CCLE	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.6507
p.I1036M	NCI-H2087	lung	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.6507
p.K1043N	SIDM00282	Colorectal Carcinoma	GDSC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.25
p.K1043N	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.25
p.K1043N	CW-2	large_intestine	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.25
p.T1019K	SIDM00100	Mesothelioma	GDSC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1944
p.T1019K	ACH-002127	Lung Cancer	CCLE	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1944
p.T1019K	H2595	pleura	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.1944
p.H1043Q	DU-145	prostate	COSMIC	LAPLALPEQALLI	DEG_ODPH_VHL_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPLALPEQALLI

Degron related mutations and impact score

Drug responses associated with ZNF804A mutations

All proteins holding degron of LAPLALPEQALLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z570	Zinc finger protein 804A	DEG_ODPH_VHL_1	1024:1036	LAPLALPEQALLI	VHL	0.6534	More...