DegronMD

Uniprot ID: Q7Z570

Source protein: Zinc finger protein 804A

Source gene: ZNF804A

Class: DEG_ODPH_VHL_1

Location: 399:411

E3 ligase: VHL

DEGRON score: 0.9493

ASA_SCORE: 98.5538

COIL: 0.7949

CONS_SCORE: 0.4534

DSS_SCORE: 0.52

HELIX: 0.1662

FCONS_SCORE: 0.936

RIG_SCORE: 0.7366

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E397K	TCGA-09-1674	OV	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.2778
p.E397K	DO31050	OV	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.2778
p.P401T	TCGA-21-1076	LUSC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.7031
p.P401T	DO26599	LUSC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.7031
p.E389D	TCGA-55-8203	LUAD	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.0556
p.E389D	DO218928	LUAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.0556
p.P396T	TCGA-66-2759	LUSC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.25
p.P396T	DO27326	LUSC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.25
p.V407F	TCGA-86-7714	LUAD	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.5957
p.V407F	DO24870	LUAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.5957
p.G395C	TCGA-98-A539	LUSC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.2222
p.G395C	DO52022	LUSC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.2222
p.K414T	TCGA-AX-A2HC	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.3611
p.K414T	DO41572	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.3611
p.E397D	TCGA-B5-A3FA	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.2778
p.E397D	DO52402	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.2778
p.P401S	TCGA-B5-A3FA	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6752
p.P401S	TCGA-BF-A3DJ	SKCM	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6752
p.P401S	TCGA-EE-A29T	SKCM	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6752
p.P401S	DO37742	SKCM	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6752
p.P401S	DO51237	SKCM	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6752
p.P401S	DO52402	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6752
p.I411M	TCGA-BR-8680	STAD	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6507
p.I411M	DO47769	STAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6507
p.F417L	TCGA-BS-A0TC	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.1667
p.F417L	DO42400	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.1667
p.Q421E	TCGA-BS-A0UV	UCEC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.0556
p.Q421E	DO42793	UCEC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.0556
p.T410N	TCGA-CQ-5327	HNSC	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.5944
p.T410N	DO15878	HNSC	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.5944
p.E405K	TCGA-WE-A8ZX	SKCM	TCGA	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.591
p.E405K	DO51291	SKCM	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.591
p.N403H	DO10858	ESAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6312
p.N403H	DO233642	GACA	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6312
p.V407D	DO32916	PACA	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6674
p.V407D	SIDM00957	Colorectal Carcinoma	GDSC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6674
p.V407D	COLO-678	large_intestine	COSMIC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.6674
p.K419E	DO233509	PRAD	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.2222
p.G395S	DO219878	SKCA	ICGC	LAPSNTEEVNITI	DEG_ODPH_VHL_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPSNTEEVNITI

Degron related mutations and impact score

Drug responses associated with ZNF804A mutations

All proteins holding degron of LAPSNTEEVNITI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z570	Zinc finger protein 804A	DEG_ODPH_VHL_1	399:411	LAPSNTEEVNITI	VHL	0.9493	More...