DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SPOP_SBC_1

Location: 1609:1613

E3 ligase: SPOP

DEGRON score: 0.9382

ASA_SCORE: 92.52

COIL: 0.9134

CONS_SCORE: 0.2707

DSS_SCORE: 0.4084

HELIX: 0.0238

FCONS_SCORE: 0.9186

RIG_SCORE: 0.7304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1622P	TCGA-CG-5721	STAD	TCGA	VETSS	DEG_SPOP_SBC_1	0.0833
p.E1610K	DO229036	LICA	ICGC	VETSS	DEG_SPOP_SBC_1	0.591
p.S1612P	DO38192	STAD	ICGC	VETSS	DEG_SPOP_SBC_1	0.6752
p.A1622T	DO42881	UCEC	ICGC	VETSS	DEG_SPOP_SBC_1	0.0833
p.T1614A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.3056
p.V1609I	SIDM00875	Breast Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.7076
p.V1609I	ACH-000624	Breast Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.7076
p.V1609I	HCC1806	breast	COSMIC	VETSS	DEG_SPOP_SBC_1	0.7076
p.P1606S	SIDM00126	Melanoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.25
p.P1606S	ACH-002147	Skin Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.25
p.P1606S	K2	skin	COSMIC	VETSS	DEG_SPOP_SBC_1	0.25
p.G1605C	SIDM00839	Colorectal Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.2222
p.G1605C	ACH-000950	Colon/Colorectal Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.2222
p.G1605C	LoVo	large_intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	0.2222
p.T1611M	SNU-1040	large_intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	0.7423
p.V1599I	HCC1806	breast	COSMIC	VETSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1609:1613	VETSS	SPOP	0.9382	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	477:481	VETSS	SPOP	0.9644	More...
Q86UP2	Kinectin	DEG_SPOP_SBC_1	105:109	VETSS	SPOP	0.9538	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2459:2463	VETSS	SPOP	0.921	More...
Q7Z3V4	Ubiquitin-protein ligase E3B	DEG_SPOP_SBC_1	671:675	VETSS	SPOP	0.902	More...
Q5VYV7	Protein SLX4IP	DEG_SPOP_SBC_1	190:194	VETSS	SPOP	0.9987	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	27:31	VETSS	SPOP	0.9983	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	34:38	VETSS	SPOP	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons