DegronMD

Uniprot ID: Q7Z3V4

Source protein: Ubiquitin-protein ligase E3B

Source gene: UBE3B

Class: DEG_SPOP_SBC_1

Location: 671:675

E3 ligase: SPOP

DEGRON score: 0.902

ASA_SCORE: 76.5

COIL: 0.8122

CONS_SCORE: 0.3154

DSS_SCORE: 0.4626

HELIX: 0.1214

FCONS_SCORE: 0.7375

RIG_SCORE: 0.7081

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P678Q	TCGA-EE-A2GE	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.25
p.P678Q	DO38016	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.25
p.S675F	TCGA-FS-A1ZD	SKCM	TCGA	VETSS	DEG_SPOP_SBC_1	0.9093
p.S675F	DO37627	SKCM	ICGC	VETSS	DEG_SPOP_SBC_1	0.9093
p.H682Y	TCGA-ZF-A9RC	BLCA	TCGA	VETSS	DEG_SPOP_SBC_1	0.1389
p.H682Y	DO219068	BLCA	ICGC	VETSS	DEG_SPOP_SBC_1	0.1389
p.I685T	ACH-002248	Neuroblastoma	CCLE	VETSS	DEG_SPOP_SBC_1	0.0556
p.T684P	ACH-002361	Non-Cancerous	CCLE	VETSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1609:1613	VETSS	SPOP	0.9382	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	477:481	VETSS	SPOP	0.9644	More...
Q86UP2	Kinectin	DEG_SPOP_SBC_1	105:109	VETSS	SPOP	0.9538	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2459:2463	VETSS	SPOP	0.921	More...
Q7Z3V4	Ubiquitin-protein ligase E3B	DEG_SPOP_SBC_1	671:675	VETSS	SPOP	0.902	More...
Q5VYV7	Protein SLX4IP	DEG_SPOP_SBC_1	190:194	VETSS	SPOP	0.9987	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	27:31	VETSS	SPOP	0.9983	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	34:38	VETSS	SPOP	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons