DegronMD - Q86UP2(KTN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S156C	TCGA-AX-A2HK	UCEC	TCGA	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation altering degron motif	0.7541
p.S156C	DO42889	UCEC	ICGC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation altering degron motif	0.7541
p.K119T	TCGA-AZ-4315	COAD	TCGA	VETSS	DEG_SPOP_SBC_1	105:109	Mutation substituting flanking lysine	0.1667
p.K119T	DO8842	COAD	ICGC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation substituting flanking lysine	0.1667
p.P99S	TCGA-DU-6407	LGG	TCGA	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.1667
p.P99S	DO22295	LGG	ICGC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.1667
p.V111F	TCGA-FV-A3I0	LIHC	TCGA	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.2778
p.V111F	DO45009	LIHC	ICGC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.2778
p.Q987H	TCGA-G4-6627	COAD	TCGA	FPPHEE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.2222
p.Q987H	DO9098	COAD	ICGC	FPPHEE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.2222
p.P154S	TCGA-GN-A9SD	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation altering degron motif	0.6752
p.P154S	DO51263	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation altering degron motif	0.6752
p.P99L	DO48200	ESCA	ICGC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.1667
p.D95Y	DO229015	LICA	ICGC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.0556
p.A160S	DO229029	LICA	ICGC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation rewiring degron network	0.25
p.P101L	DO220889	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.2222
p.E113A	DO222824	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.2222
p.K150N	DO46380	OV	ICGC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation rewiring degron network	0.2778
p.S161L	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation blocking phosphorylation signal	0.6667
p.P165A	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation rewiring degron network	0.1111
p.L102W	SIDM00118	Colorectal Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.25
p.L102W	ACH-001081	Colon/Colorectal Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.25
p.L102W	HCC2998	large intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.25
p.V148I	SIDM01640	Acute Myeloid Leukemia	GDSC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation rewiring degron network	0.2222
p.V148I	ACH-000602	Leukemia	CCLE	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation rewiring degron network	0.2222
p.Q982E	ACH-000629	Brain Cancer	CCLE	FPPHEE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.0833
p.Q1002R	SNU-1040	large intestine	COSMIC	FPPHEE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.1667
p.Q158E	HARA	lung	COSMIC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation rewiring degron network	0.3056
p.S994F	SW684	soft tissue	COSMIC	FPPHEE	LIG_APCC_ABBA_1	991:996	Mutation altering degron motif	0.7982
p.D997V	CL-34	large intestine	COSMIC	FPPHEE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.3056
p.I153M	Ca-Ski	cervix	COSMIC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation altering degron motif	0.7618
p.E110G	CW-2	large intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	105:109	Mutation blocking phosphorylation signal	0.75
p.Y144H	SNU-1040	large intestine	COSMIC	PTPPSE	DEG_SCF_FBW7_2	152:157	Mutation rewiring degron network	0.1111

Kaplan plot for KTN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KTN1

UniProt ID: Q86UP2

Entrez ID: 3895

Protein name: Kinectin (CG-1 antigen) (Kinesin receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KTN1 in