DegronMD

Uniprot ID: Q86UP2

Source protein: Kinectin

Source gene: KTN1

Class: DEG_SPOP_SBC_1

Location: 105:109

E3 ligase: SPOP

DEGRON score: 0.9538

ASA_SCORE: 95.18

COIL: 0.8804

CONS_SCORE: 0.7558

DSS_SCORE: 0.4739

HELIX: 0.1042

FCONS_SCORE: 0.9791

RIG_SCORE: 0.7331

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K119T	TCGA-AZ-4315	COAD	TCGA	VETSS	DEG_SPOP_SBC_1	0.1667
p.K119T	DO8842	COAD	ICGC	VETSS	DEG_SPOP_SBC_1	0.1667
p.P99S	TCGA-DU-6407	LGG	TCGA	VETSS	DEG_SPOP_SBC_1	0.1667
p.P99S	DO22295	LGG	ICGC	VETSS	DEG_SPOP_SBC_1	0.1667
p.V111F	TCGA-FV-A3I0	LIHC	TCGA	VETSS	DEG_SPOP_SBC_1	0.2778
p.V111F	DO45009	LIHC	ICGC	VETSS	DEG_SPOP_SBC_1	0.2778
p.P99L	DO48200	ESCA	ICGC	VETSS	DEG_SPOP_SBC_1	0.1667
p.D95Y	DO229015	LICA	ICGC	VETSS	DEG_SPOP_SBC_1	0.0556
p.P101L	DO220889	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	0.2222
p.E113A	DO222824	MELA	ICGC	VETSS	DEG_SPOP_SBC_1	0.2222
p.L102W	SIDM00118	Colorectal Carcinoma	GDSC	VETSS	DEG_SPOP_SBC_1	0.25
p.L102W	ACH-001081	Colon/Colorectal Cancer	CCLE	VETSS	DEG_SPOP_SBC_1	0.25
p.L102W	HCC2998	large_intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	0.25
p.E110G	CW-2	large_intestine	COSMIC	VETSS	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1609:1613	VETSS	SPOP	0.9382	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	477:481	VETSS	SPOP	0.9644	More...
Q86UP2	Kinectin	DEG_SPOP_SBC_1	105:109	VETSS	SPOP	0.9538	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2459:2463	VETSS	SPOP	0.921	More...
Q7Z3V4	Ubiquitin-protein ligase E3B	DEG_SPOP_SBC_1	671:675	VETSS	SPOP	0.902	More...
Q5VYV7	Protein SLX4IP	DEG_SPOP_SBC_1	190:194	VETSS	SPOP	0.9987	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	27:31	VETSS	SPOP	0.9983	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	34:38	VETSS	SPOP	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons