DegronMD

Uniprot ID: Q86UP2

Source protein: Kinectin

Source gene: KTN1

Class: DEG_SCF_FBW7_2

Location: 152:157

E3 ligase: FBXW7

DEGRON score: 0.9473

ASA_SCORE: 92.3167

COIL: 0.9072

CONS_SCORE: 0.8145

DSS_SCORE: 0.7182

HELIX: 0.0832

FCONS_SCORE: 1.0398

RIG_SCORE: 0.5906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S156C	TCGA-AX-A2HK	UCEC	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.7541
p.S156C	DO42889	UCEC	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.7541
p.P154S	TCGA-GN-A9SD	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.6752
p.P154S	DO51263	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.6752
p.A160S	DO229029	LICA	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.25
p.K150N	DO46380	OV	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.2778
p.S161L	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPSE	DEG_SCF_FBW7_2	0.6667
p.P165A	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPSE	DEG_SCF_FBW7_2	0.1111
p.V148I	SIDM01640	Acute Myeloid Leukemia	GDSC	PTPPSE	DEG_SCF_FBW7_2	0.2222
p.V148I	ACH-000602	Leukemia	CCLE	PTPPSE	DEG_SCF_FBW7_2	0.2222
p.Q158E	HARA	lung	COSMIC	PTPPSE	DEG_SCF_FBW7_2	0.3056
p.I153M	Ca-Ski	cervix	COSMIC	PTPPSE	DEG_SCF_FBW7_2	0.7618
p.Y144H	SNU-1040	large_intestine	COSMIC	PTPPSE	DEG_SCF_FBW7_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons