DegronMD - P58004(SESN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P228H	TCGA-A6-5665	COAD	TCGA	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.25
p.P228H	DO9756	COAD	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.25
p.P240S	TCGA-AJ-A3EK	UCEC	TCGA	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.2222
p.P240S	DO41584	UCEC	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.2222
p.A227V	TCGA-AP-A1DK	UCEC	TCGA	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.2222
p.A227V	DO42033	UCEC	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.2222
p.P228S	TCGA-DF-A2KU	UCEC	TCGA	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.25
p.P228S	DO223286	UCEC	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.25
p.P228S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.25
p.P245S	TCGA-EE-A180	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.0833
p.P245S	DO47537	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.0833
p.P245L	TCGA-EE-A180	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.0833
p.P245L	DO47537	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.0833
p.P234S	TCGA-FR-A728	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation altering degron motif	0.5641
p.P234S	DO222843	MELA	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation altering degron motif	0.5641
p.P234S	DO48550	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation altering degron motif	0.5641
p.P234H	TCGA-GN-A263	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation altering degron motif	0.6583
p.P234H	DO37766	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation altering degron motif	0.6583
p.P233L	DO230336	COCA	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation altering degron motif	0.7582
p.L246F	DO229025	LICA	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.0556
p.S242G	DO222494	MELA	ICGC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.1667
p.Q229H	SIDM01045	Endometrial Carcinoma	GDSC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.2778
p.Q229H	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.2778
p.Q229H	EN	endometrium	COSMIC	PTPPSE	DEG_SCF_FBW7_2	231:236	Mutation rewiring degron network	0.2778

Kaplan plot for SESN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SESN2

UniProt ID: P58004

Entrez ID: 83667

Protein name: Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SESN2 in