DegronMD

Uniprot ID: P58004

Source protein: Sestrin-2

Source gene: SESN2

Class: DEG_SCF_FBW7_2

Location: 231:236

E3 ligase: FBXW7

DEGRON score: 0.9684

ASA_SCORE: 79.1333

COIL: 0.9055

CONS_SCORE: 0.3803

DSS_SCORE: 0.9153

HELIX: 0.0663

FCONS_SCORE: 1.1362

RIG_SCORE: 0.5137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P228H	TCGA-A6-5665	COAD	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.25
p.P228H	DO9756	COAD	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.25
p.P240S	TCGA-AJ-A3EK	UCEC	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.2222
p.P240S	DO41584	UCEC	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.2222
p.A227V	TCGA-AP-A1DK	UCEC	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.2222
p.A227V	DO42033	UCEC	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.2222
p.P228S	TCGA-DF-A2KU	UCEC	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.25
p.P228S	DO223286	UCEC	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.25
p.P228S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PTPPSE	DEG_SCF_FBW7_2	0.25
p.P245S	TCGA-EE-A180	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.0833
p.P245S	DO47537	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.0833
p.P245L	TCGA-EE-A180	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.0833
p.P245L	DO47537	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.0833
p.P234S	TCGA-FR-A728	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.5641
p.P234S	DO222843	MELA	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.5641
p.P234S	DO48550	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.5641
p.P234H	TCGA-GN-A263	SKCM	TCGA	PTPPSE	DEG_SCF_FBW7_2	0.6583
p.P234H	DO37766	SKCM	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.6583
p.P233L	DO230336	COCA	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.7582
p.L246F	DO229025	LICA	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.0556
p.S242G	DO222494	MELA	ICGC	PTPPSE	DEG_SCF_FBW7_2	0.1667
p.Q229H	SIDM01045	Endometrial Carcinoma	GDSC	PTPPSE	DEG_SCF_FBW7_2	0.2778
p.Q229H	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTPPSE	DEG_SCF_FBW7_2	0.2778
p.Q229H	EN	endometrium	COSMIC	PTPPSE	DEG_SCF_FBW7_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons