DegronMD

Uniprot ID: Q86UP2

Source protein: Kinectin

Source gene: KTN1

Class: LIG_APCC_ABBA_1

Location: 991:996

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5436

ASA_SCORE: 106.4667

COIL: 0.478

CONS_SCORE: 0.7692

DSS_SCORE: 0.4377

HELIX: 0.5142

FCONS_SCORE: 1.0296

RIG_SCORE: 0.7154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q987H	TCGA-G4-6627	COAD	TCGA	FPPHEE	LIG_APCC_ABBA_1	0.2222
p.Q987H	DO9098	COAD	ICGC	FPPHEE	LIG_APCC_ABBA_1	0.2222
p.Q982E	ACH-000629	Brain Cancer	CCLE	FPPHEE	LIG_APCC_ABBA_1	0.0833
p.Q1002R	SNU-1040	large_intestine	COSMIC	FPPHEE	LIG_APCC_ABBA_1	0.1667
p.S994F	SW684	soft_tissue	COSMIC	FPPHEE	LIG_APCC_ABBA_1	0.7982
p.D997V	CL-34	large_intestine	COSMIC	FPPHEE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UP2	Kinectin	LIG_APCC_ABBA_1	991:996	FPPHEE	APC,CDC20,FZR1	0.5436	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons