DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SCF_FBW7_1

Location: 435:441

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 79.3286

COIL: 0.9093

CONS_SCORE: 0.2991

DSS_SCORE: 0.841

HELIX: 0.0431

FCONS_SCORE: 1.027

RIG_SCORE: 0.5498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P444T	TCGA-A5-A1OF	UCEC	TCGA	PTTPTSS	DEG_SCF_FBW7_1	0.25
p.P444T	DO42568	UCEC	ICGC	PTTPTSS	DEG_SCF_FBW7_1	0.25
p.S433R	TCGA-VQ-A8P8	STAD	TCGA	PTTPTSS	DEG_SCF_FBW7_1	0.7222
p.S433R	DO51764	STAD	ICGC	PTTPTSS	DEG_SCF_FBW7_1	0.7222
p.T446I	DO233942	GACA	ICGC	PTTPTSS	DEG_SCF_FBW7_1	0.3056
p.A451S	DO229026	LICA	ICGC	PTTPTSS	DEG_SCF_FBW7_1	0.0556
p.A443T	DO229216	THCA	ICGC	PTTPTSS	DEG_SCF_FBW7_1	0.2778
p.P431S	SIDM00481	Ovarian Carcinoma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	0.2222
p.P431S	SIDM00098	Mesothelioma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	0.2222
p.P431S	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	0.2222
p.P431S	SIDM00221	Melanoma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	0.2222
p.P431S	SIDM00999	Bladder Carcinoma	GDSC	PTTPTSS	DEG_SCF_FBW7_1	0.2222
p.P432S	K2	skin	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	0.25
p.T439P	DU-145	prostate	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	0.7031
p.G431C	LoVo	large_intestine	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	0.2222
p.V435I	HCC1806	breast	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	0.7076
p.T447M	SNU-1040	large_intestine	COSMIC	PTTPTSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SCF_FBW7_1	435:441	PTTPTSS	FBXW7	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons