DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SPOP_SBC_1

Location: 1392:1396

E3 ligase: SPOP

DEGRON score: 0.9858

ASA_SCORE: 84.8

COIL: 0.9374

CONS_SCORE: 0.2851

DSS_SCORE: 0.5662

HELIX: 0.018

FCONS_SCORE: 0.9438

RIG_SCORE: 0.6965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1382M	TCGA-49-4487	LUAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.1667
p.K1382M	DO24780	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1667
p.P1400A	TCGA-AA-3864	COAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.2222
p.P1400A	DO8490	COAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.2222
p.P1386L	TCGA-EE-A2GR	SKCM	TCGA	ATTTS	DEG_SPOP_SBC_1	0.1667
p.H1383Y	TCGA-EY-A2OQ	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.0833
p.T1384M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ATTTS	DEG_SPOP_SBC_1	0.1111
p.T1384M	ACH-001737	Leukemia	CCLE	ATTTS	DEG_SPOP_SBC_1	0.1111
p.T1384M	ACH-002222	Leukemia	CCLE	ATTTS	DEG_SPOP_SBC_1	0.1111
p.T1384M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.1111
p.F1399L	NCI-H345	lung	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	579:583	ATTTS	SPOP	0.9843	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1392:1396	ATTTS	SPOP	0.9858	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	279:283	ATTTS	SPOP	0.9569	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1293:1297	ATTTS	SPOP	0.9752	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2383:2387	ATTTS	SPOP	0.9073	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2407:2411	ATTTS	SPOP	0.7108	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2559:2563	ATTTS	SPOP	0.8562	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2623:2627	ATTTS	SPOP	0.977	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2767:2771	ATTTS	SPOP	0.6283	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2775:2779	ATTTS	SPOP	0.8646	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2927:2931	ATTTS	SPOP	0.9402	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3449:3453	ATTTS	SPOP	0.6496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	698:702	ATTTS	SPOP	0.9575	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	431:435	ATTTS	SPOP	0.9917	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	237:241	ATTTS	SPOP	0.9908	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1425:1429	ATTTS	SPOP	0.9547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons