DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ATTTS
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
2623:2627
E3 ligase:
SPOP
DEGRON score:
0.977
ASA_SCORE:
82.04
COIL:
0.8982
CONS_SCORE:
0.3222
DSS_SCORE:
0.667
HELIX:
0.0236
FCONS_SCORE:
1.0703
RIG_SCORE:
0.6636
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P2632S
SIDM00329
Hodgkin's Lymphoma
GDSC
ATTTS
DEG_SPOP_SBC_1
0.1944
p.S2627G
SIDM01105
Melanoma
GDSC
ATTTS
DEG_SPOP_SBC_1
0.6993
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ATTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00268
Transcription initiation factor TFIID subunit 4
DEG_SPOP_SBC_1
579:583
ATTTS
SPOP
0.9843
More...
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
1392:1396
ATTTS
SPOP
0.9858
More...
P37198
Nuclear pore glycoprotein p62
DEG_SPOP_SBC_1
279:283
ATTTS
SPOP
0.9569
More...
P49790
Nuclear pore complex protein Nup153
DEG_SPOP_SBC_1
1293:1297
ATTTS
SPOP
0.9752
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2383:2387
ATTTS
SPOP
0.9073
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2407:2411
ATTTS
SPOP
0.7108
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2559:2563
ATTTS
SPOP
0.8562
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2623:2627
ATTTS
SPOP
0.977
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2767:2771
ATTTS
SPOP
0.6283
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2775:2779
ATTTS
SPOP
0.8646
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2927:2931
ATTTS
SPOP
0.9402
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3449:3453
ATTTS
SPOP
0.6496
More...
Q12830
Nucleosome-remodeling factor subunit BPTF
DEG_SPOP_SBC_1
698:702
ATTTS
SPOP
0.9575
More...
Q9UIU6
Homeobox protein SIX4
DEG_SPOP_SBC_1
431:435
ATTTS
SPOP
0.9917
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
237:241
ATTTS
SPOP
0.9908
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
1425:1429
ATTTS
SPOP
0.9547
More...