DegronMD - O00268(TAF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V593M	TCGA-44-3396	LUAD	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556
p.V593M	TCGA-Q1-A6DV	CESC	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556
p.V593M	DO44334	CESC	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556
p.V593M	DO23559	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556
p.G578W	TCGA-55-6979	LUAD	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.3056
p.G578W	DO24110	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.3056
p.S687P	TCGA-A6-6780	COAD	TCGA	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.S687P	DO10244	COAD	ICGC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.A579V	TCGA-AF-5654	READ	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.5825
p.A579V	DO36647	READ	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.5825
p.E591D	TCGA-AN-A046	BRCA	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1111
p.E591D	DO1285	BRCA	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1111
p.V593L	TCGA-B5-A1MY	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556
p.V593L	DO43859	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556
p.T709M	TCGA-BR-A4J4	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1111
p.T709M	TCGA-D1-A167	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1111
p.T709M	DO38671	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1111
p.T709M	DO40978	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1111
p.R574S	TCGA-DA-A3F5	SKCM	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1944
p.R574S	DO37435	SKCM	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1944
p.N592H	TCGA-DF-A2KU	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0833
p.N592H	DO223286	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0833
p.A711T	TCGA-EA-A3HU	CESC	TCGA	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.A711T	DO6320	CESC	ICGC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.V576A	TCGA-F2-A7TX	PAAD	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.V576A	DO50254	PAAD	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.V696A	TCGA-HU-A4GN	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.3056
p.V696A	DO47833	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.3056
p.R574C	TCGA-KQ-A41N	BLCA	TCGA	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1944
p.R574C	DO223588	BLCA	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1944
p.A692V	TCGA-OR-A5KB	ACC	TCGA	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1944
p.V696M	TCGA-WB-A821	PCPG	TCGA	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.3056
p.A706T	TCGA-XK-AAIW	PRAD	TCGA	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1944
p.A706T	DO51407	PRAD	ICGC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1944
p.A425S	DO555	BLCA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	412:419	Mutation rewiring degron network	0.1667
p.T575M	DO222427	BTCA	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.T419P	DO233693	GACA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	412:419	Mutation altering degron motif	0.7031
p.T419P	ACH-001356	Thyroid Cancer	CCLE	LSRTPTAT	DEG_SCF_FBW7_1	412:419	Mutation altering degron motif	0.7031
p.A710T	DO233732	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0833
p.R574H	DO233885	GACA	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1944
p.A404E	DO228940	LICA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	412:419	Mutation rewiring degron network	0.1111
p.L427M	DO228952	LICA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	412:419	Mutation rewiring degron network	0.1111
p.L412M	DO229026	LICA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	412:419	Mutation altering degron motif	0.5999
p.A586V	DO232761	PBCA	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.P577S	DO229459	SKCA	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2778
p.T571A	DO229259	THCA	ICGC	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation blocking phosphorylation signal	0.5556
p.A425D	SIDM01314	Colorectal Carcinoma	GDSC	LSRTPTAT	DEG_SCF_FBW7_1	412:419	Mutation rewiring degron network	0.1667
p.S687L	SIDM00707	Non-Cancerous	GDSC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.S687L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.A695T	SIDM01059	Melanoma	GDSC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.2778
p.A695T	ACH-000915	Skin Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.2778
p.A695T	IPC-298	skin	COSMIC	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.2778
p.A586T	ACH-000998	Colon/Colorectal Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.S583P	ACH-001664	Gastric Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.6752
p.G707R	ACH-001719	Ovarian Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1667

Kaplan plot for TAF4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF4

UniProt ID: O00268

Entrez ID: 6874

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAF4 in