DegronMD

Uniprot ID: O00268

Source protein: Transcription initiation factor TFIID subunit 4

Source gene: TAF4

Class: DEG_SPOP_SBC_1

Location: 579:583

E3 ligase: SPOP

DEGRON score: 0.9843

ASA_SCORE: 76.2

COIL: 0.8686

CONS_SCORE: 0.3407

DSS_SCORE: 0.5859

HELIX: 0.052

FCONS_SCORE: 1.0274

RIG_SCORE: 0.6975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V593M	TCGA-44-3396	LUAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.0556
p.V593M	TCGA-Q1-A6DV	CESC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.0556
p.V593M	DO44334	CESC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.0556
p.V593M	DO23559	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.0556
p.G578W	TCGA-55-6979	LUAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.3056
p.G578W	DO24110	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.3056
p.A579V	TCGA-AF-5654	READ	TCGA	ATTTS	DEG_SPOP_SBC_1	0.5825
p.A579V	DO36647	READ	ICGC	ATTTS	DEG_SPOP_SBC_1	0.5825
p.E591D	TCGA-AN-A046	BRCA	TCGA	ATTTS	DEG_SPOP_SBC_1	0.1111
p.E591D	DO1285	BRCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1111
p.V593L	TCGA-B5-A1MY	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.0556
p.V593L	DO43859	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.0556
p.R574S	TCGA-DA-A3F5	SKCM	TCGA	ATTTS	DEG_SPOP_SBC_1	0.1944
p.R574S	DO37435	SKCM	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1944
p.N592H	TCGA-DF-A2KU	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.0833
p.N592H	DO223286	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.0833
p.V576A	TCGA-F2-A7TX	PAAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.25
p.V576A	DO50254	PAAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.25
p.R574C	TCGA-KQ-A41N	BLCA	TCGA	ATTTS	DEG_SPOP_SBC_1	0.1944
p.R574C	DO223588	BLCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1944
p.T575M	DO222427	BTCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.2222
p.R574H	DO233885	GACA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1944
p.A586V	DO232761	PBCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.25
p.P577S	DO229459	SKCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.2778
p.T571A	DO229259	THCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.5556
p.A586T	ACH-000998	Colon/Colorectal Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	0.25
p.S583P	ACH-001664	Gastric Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	579:583	ATTTS	SPOP	0.9843	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1392:1396	ATTTS	SPOP	0.9858	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	279:283	ATTTS	SPOP	0.9569	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1293:1297	ATTTS	SPOP	0.9752	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2383:2387	ATTTS	SPOP	0.9073	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2407:2411	ATTTS	SPOP	0.7108	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2559:2563	ATTTS	SPOP	0.8562	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2623:2627	ATTTS	SPOP	0.977	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2767:2771	ATTTS	SPOP	0.6283	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2775:2779	ATTTS	SPOP	0.8646	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2927:2931	ATTTS	SPOP	0.9402	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3449:3453	ATTTS	SPOP	0.6496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	698:702	ATTTS	SPOP	0.9575	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	431:435	ATTTS	SPOP	0.9917	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	237:241	ATTTS	SPOP	0.9908	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1425:1429	ATTTS	SPOP	0.9547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons