DegronMD

Uniprot ID: P37198

Source protein: Nuclear pore glycoprotein p62

Source gene: NUP62

Class: DEG_SPOP_SBC_1

Location: 279:283

E3 ligase: SPOP

DEGRON score: 0.9569

ASA_SCORE: 81.94

COIL: 0.9306

CONS_SCORE: 0.3973

DSS_SCORE: 0.4432

HELIX: 0.0214

FCONS_SCORE: 0.9085

RIG_SCORE: 0.7122

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T280A	TCGA-BR-8591	STAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.6028
p.T280A	DO233888	GACA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6028
p.T280A	DO47973	STAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6028
p.T282S	TCGA-CG-4306	STAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.6005
p.T282S	DO230343	COCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.T282S	DO38567	STAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.T282S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.T288A	DO230346	COCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1944
p.S283T	DO229010	COCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.S283T	DO229016	COCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.S283T	DO229003	COCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.S283T	DO229005	COCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.S283T	DO230999	LUSC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.S283T	DO231049	LUSC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.T276N	DO223058	ESCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.25
p.T281A	DO233109	GACA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.825
p.T281A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.825
p.T281A	ACH-000717	Esophageal Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	0.825
p.A275D	DO228952	LICA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.2222
p.T281I	DO229052	LICA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.8189
p.L292F	DO27811	MALY	ICGC	ATTTS	DEG_SPOP_SBC_1	0.0833
p.G289D	DO27779	MALY	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1667
p.G289S	DO232858	NACA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1667
p.A279T	SIDM01943	Colorectal Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.7139
p.A279T	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.7139
p.A279T	SIDM01752	Pancreatic Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.7139
p.T287S	SIDM00602	Gastric Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.2222
p.A277V	SIDM00217	Colorectal Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.2778
p.A277V	ACH-000999	Colon/Colorectal Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	0.2778
p.A275V	SIDM01617	Endometrial Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.2222
p.A275V	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	0.2222
p.S283N	SIDM01587	Bladder Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	579:583	ATTTS	SPOP	0.9843	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1392:1396	ATTTS	SPOP	0.9858	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	279:283	ATTTS	SPOP	0.9569	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1293:1297	ATTTS	SPOP	0.9752	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2383:2387	ATTTS	SPOP	0.9073	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2407:2411	ATTTS	SPOP	0.7108	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2559:2563	ATTTS	SPOP	0.8562	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2623:2627	ATTTS	SPOP	0.977	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2767:2771	ATTTS	SPOP	0.6283	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2775:2779	ATTTS	SPOP	0.8646	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2927:2931	ATTTS	SPOP	0.9402	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3449:3453	ATTTS	SPOP	0.6496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	698:702	ATTTS	SPOP	0.9575	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	431:435	ATTTS	SPOP	0.9917	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	237:241	ATTTS	SPOP	0.9908	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1425:1429	ATTTS	SPOP	0.9547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTS

Degron related mutations and impact score

Drug responses associated with NUP62 mutations

All proteins holding degron of ATTTS