DegronMD

Uniprot ID: Q9UIU6

Source protein: Homeobox protein SIX4

Source gene: SIX4

Class: DEG_SPOP_SBC_1

Location: 431:435

E3 ligase: SPOP

DEGRON score: 0.9917

ASA_SCORE: 85.62

COIL: 0.921

CONS_SCORE: 0.3327

DSS_SCORE: 0.3892

HELIX: 0.0428

FCONS_SCORE: 0.8763

RIG_SCORE: 0.6692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S435C	TCGA-94-8035	LUSC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.7541
p.S435C	DO219173	LUSC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.7541
p.T432S	TCGA-D5-6529	COAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.6005
p.T432S	DO10758	COAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6005
p.P438S	TCGA-EO-A22R	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.25
p.P438S	DO42713	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.25
p.F421L	TCGA-EO-A3B0	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.0556
p.F421L	DO219773	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.0556
p.V440I	TCGA-IB-7651	PAAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.1944
p.V440I	DO46657	PAAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1944
p.S439G	DO233109	GACA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.6667
p.P445T	DO229015	LICA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.0556
p.V423I	SIDM01164	Glioma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.1111
p.V423I	SW1783	central_nervous_system	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	579:583	ATTTS	SPOP	0.9843	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1392:1396	ATTTS	SPOP	0.9858	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	279:283	ATTTS	SPOP	0.9569	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1293:1297	ATTTS	SPOP	0.9752	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2383:2387	ATTTS	SPOP	0.9073	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2407:2411	ATTTS	SPOP	0.7108	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2559:2563	ATTTS	SPOP	0.8562	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2623:2627	ATTTS	SPOP	0.977	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2767:2771	ATTTS	SPOP	0.6283	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2775:2779	ATTTS	SPOP	0.8646	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2927:2931	ATTTS	SPOP	0.9402	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3449:3453	ATTTS	SPOP	0.6496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	698:702	ATTTS	SPOP	0.9575	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	431:435	ATTTS	SPOP	0.9917	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	237:241	ATTTS	SPOP	0.9908	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1425:1429	ATTTS	SPOP	0.9547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons