DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 1293:1297

E3 ligase: SPOP

DEGRON score: 0.9752

ASA_SCORE: 82.92

COIL: 0.918

CONS_SCORE: 0.4433

DSS_SCORE: 0.3504

HELIX: 0.025

FCONS_SCORE: 0.9951

RIG_SCORE: 0.7217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1299A	TCGA-F4-6703	COAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.2778
p.S1299A	DO9908	COAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.2778
p.S1299C	TCGA-LP-A5U2	CESC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.2778
p.S1299C	DO51610	CESC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.2778
p.S1287F	DO50354	ESAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1667
p.V1305L	DO229208	THCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1111
p.L1291P	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	0.2778
p.L1291P	NCI-H2170	lung	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.2778
p.A1293V	ACH-001518	Endometrial/Uterine Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	0.5825
p.S1301F	EC-GI-10	oesophagus	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.2222
p.I1302L	IST-MEL1	skin	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.1944
p.T1284I	SISO	cervix	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	579:583	ATTTS	SPOP	0.9843	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1392:1396	ATTTS	SPOP	0.9858	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	279:283	ATTTS	SPOP	0.9569	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1293:1297	ATTTS	SPOP	0.9752	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2383:2387	ATTTS	SPOP	0.9073	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2407:2411	ATTTS	SPOP	0.7108	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2559:2563	ATTTS	SPOP	0.8562	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2623:2627	ATTTS	SPOP	0.977	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2767:2771	ATTTS	SPOP	0.6283	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2775:2779	ATTTS	SPOP	0.8646	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2927:2931	ATTTS	SPOP	0.9402	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3449:3453	ATTTS	SPOP	0.6496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	698:702	ATTTS	SPOP	0.9575	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	431:435	ATTTS	SPOP	0.9917	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	237:241	ATTTS	SPOP	0.9908	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1425:1429	ATTTS	SPOP	0.9547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons