DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_SPOP_SBC_1

Location: 698:702

E3 ligase: SPOP

DEGRON score: 0.9575

ASA_SCORE: 78.42

COIL: 0.8484

CONS_SCORE: 0.2792

DSS_SCORE: 0.6768

HELIX: 0.0456

FCONS_SCORE: 1.0224

RIG_SCORE: 0.6737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I710M	TCGA-55-8208	LUAD	TCGA	ATTTS	DEG_SPOP_SBC_1	0.1111
p.I710M	DO51192	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1111
p.K701T	TCGA-AX-A0J0	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	0.7306
p.K701T	DO41133	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.7306
p.S691Y	TCGA-D3-A2JG	SKCM	TCGA	ATTTS	DEG_SPOP_SBC_1	0.1389
p.S691Y	DO47613	SKCM	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1389
p.S702F	DO461	BLCA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.7982
p.S702F	DO42336	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	0.7982
p.R697L	DO229045	LICA	ICGC	ATTTS	DEG_SPOP_SBC_1	0.3056
p.C691Y	DO24780	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	0.1389
p.C691Y	ACH-000995	Leukemia	CCLE	ATTTS	DEG_SPOP_SBC_1	0.1389
p.C691Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.1389
p.R710C	Becker	central_nervous_system	COSMIC	ATTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	579:583	ATTTS	SPOP	0.9843	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1392:1396	ATTTS	SPOP	0.9858	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	279:283	ATTTS	SPOP	0.9569	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1293:1297	ATTTS	SPOP	0.9752	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2383:2387	ATTTS	SPOP	0.9073	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2407:2411	ATTTS	SPOP	0.7108	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2559:2563	ATTTS	SPOP	0.8562	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2623:2627	ATTTS	SPOP	0.977	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2767:2771	ATTTS	SPOP	0.6283	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2775:2779	ATTTS	SPOP	0.8646	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2927:2931	ATTTS	SPOP	0.9402	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3449:3453	ATTTS	SPOP	0.6496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	698:702	ATTTS	SPOP	0.9575	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	431:435	ATTTS	SPOP	0.9917	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	237:241	ATTTS	SPOP	0.9908	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1425:1429	ATTTS	SPOP	0.9547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons