DegronMD

Uniprot ID: O00268

Source protein: Transcription initiation factor TFIID subunit 4

Source gene: TAF4

Class: DEG_SCF_FBW7_1

Location: 412:419

E3 ligase: FBXW7

DEGRON score: 0.9922

ASA_SCORE: 94.95

COIL: 0.9399

CONS_SCORE: 0.3732

DSS_SCORE: 0.604

HELIX: 0.0206

FCONS_SCORE: 1.1592

RIG_SCORE: 0.6755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A425S	DO555	BLCA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	0.1667
p.T419P	DO233693	GACA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	0.7031
p.T419P	ACH-001356	Thyroid Cancer	CCLE	LSRTPTAT	DEG_SCF_FBW7_1	0.7031
p.A404E	DO228940	LICA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	0.1111
p.L427M	DO228952	LICA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	0.1111
p.L412M	DO229026	LICA	ICGC	LSRTPTAT	DEG_SCF_FBW7_1	0.5999
p.A425D	SIDM01314	Colorectal Carcinoma	GDSC	LSRTPTAT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00268	Transcription initiation factor TFIID subunit 4	DEG_SCF_FBW7_1	412:419	LSRTPTAT	FBXW7	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons