DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
TKTSGVPSGF
Uniprot ID:
P35658
Source protein:
Nuclear pore complex protein Nup214
Source gene:
NUP214
Class:
DEG_COP1_1
Location:
1363:1372
E3 ligase:
COP1
DEGRON score:
0.9978
ASA_SCORE:
78.42
COIL:
0.9005
CONS_SCORE:
0.2705
DSS_SCORE:
0.5796
HELIX:
0.0247
FCONS_SCORE:
0.9739
RIG_SCORE:
0.6198
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K1382M
TCGA-49-4487
LUAD
TCGA
TKTSGVPSGF
DEG_COP1_1
0.1667
p.K1382M
DO24780
LUAD
ICGC
TKTSGVPSGF
DEG_COP1_1
0.1667
p.F1374C
TCGA-AX-A0J0
UCEC
TCGA
TKTSGVPSGF
DEG_COP1_1
0.2778
p.F1374C
DO41133
UCEC
ICGC
TKTSGVPSGF
DEG_COP1_1
0.2778
p.P1378S
TCGA-DA-A1IC
SKCM
TCGA
TKTSGVPSGF
DEG_COP1_1
0.1667
p.S1370L
DO228885
MALY
ICGC
TKTSGVPSGF
DEG_COP1_1
0.7667
p.P1379S
DO37430
SKCM
ICGC
TKTSGVPSGF
DEG_COP1_1
0.1389
p.V1368M
SIDM00845
Burkitt's Lymphoma
GDSC
TKTSGVPSGF
DEG_COP1_1
0.7208
p.P1377L
SIDM00837
Colorectal Carcinoma
GDSC
TKTSGVPSGF
DEG_COP1_1
0.1944
p.P1377L
ACH-000958
Colon/Colorectal Cancer
CCLE
TKTSGVPSGF
DEG_COP1_1
0.1944
p.P1377L
SW48
large_intestine
COSMIC
TKTSGVPSGF
DEG_COP1_1
0.1944
p.T1374M
CTV-1
haematopoietic_and_lymphoid_tissue
COSMIC
TKTSGVPSGF
DEG_COP1_1
0.2778
p.P1367L
SW48
large_intestine
COSMIC
TKTSGVPSGF
DEG_COP1_1
0.7582
Drug responses associated with NUP214 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TKTSGVPSGF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P35658
Nuclear pore complex protein Nup214
DEG_COP1_1
1363:1372
TKTSGVPSGF
COP1
0.9978
More...